Reyes-Vaca JG, Villegas-Valdez DMM, Bravo-Oro A, Hernández-Rodríguez HG

Language: Spanish
References: 37
Page: 148-158
PDF size: 2936.26 Kb.

ABSTRACT

Introduction: Autism spectrum disorder is a neuronal connectivity problem that affects linguistic, behavioral and social skills. It predominates in males older than 2 years, it is associated with genetic syndromes and its etiology is unknown.
Objective: To assess the integrity of the upper and lower longitudinal fascicles by magnetic resonance in autistic children without treatment and non-autistic children.
Materials and methods: Comparative, prospective and cross-sectional study with diffusion tensor images of the brain in 16 pediatric patients; 8 with Autism spectrum disorder not associated with another genetic syndrome and 8 non-autistic matched controls. The statistical analysis of the fraction of anisotropy, medium diffusion and the thickness of the superior and inferior longitudinal fascicles of the brain were evaluated and performed.
Results: Increase of the anisotropy fraction and decrease of the mean diffusion values in a significant way in the posterior part of the left superior longitudinal fascicle and a large part of the right inferior longitudinal fascicle, in Autistic patients.
Conclusion: Magnetic resonance with diffusion tensor, supports the early diagnosis of patients with Autistic spectrum disorder, demonstrating the lack of integrity of the white matter microstructure in a non-invasive way.

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