2019, Number 3
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Rev Med MD 2019; 10.11 (3)
Primary gliosarcoma, an unusual variant of glioblastoma
Jiménez-Manrique MA, Quillo-Olvera D, Ramírez-Aguilar R, Quillo-Olvera J
Language: Spanish
References: 25
Page: 240-244
PDF size: 666.27 Kb.
ABSTRACT
Gliosarcoma is an unusual tumor of the central nervous system, of low incidence, formed by a biphasic pattern by glial
cells and malignant mesenchymal elements. It is considered a variant of glioblastoma and its incidence is higher in men
1.8-3: 1-1.4; represents 2% of all glioblastomas. The most frequent location is supratentorial, especially in the temporal
lobe. The diagnosis should be timely with the support of immunohistochemistry as well as early surgical management
with subsequent chemotherapy and radiation to improve the quality of life of the patient despite having a short
survival.
We present the case of a 47-year-old male patient, who underwent surgical treatment, performing a left frontotemporal
craniotomy and obtaining a result by histopathological and immunohistochemical study of gliosarcoma.
REFERENCES
1.Stroebe H. Uber Entstehung und Bau der Gehirngliome. Beitr Pathol Anat Allg Pathol. 1895; 18: 405-486.
2.Feigen IH, Gross SW. Sarcoma arising in glioblastoma of the brain. Am J Pathol. 1955; 31: 633- 653.
3.Reis RM, Lebleblicioglu DK, Lopes JM, Kleihues P, Ohgaki H. Genetic Profile of Gliosarcomas. American Journal of Pathology 2000; 156, 2: 425-432,.
Serratos FF, Herrera SF, Jaimez RJ, García VF, Aguilar GN, Serratos FV, Ramírez SA, Martínez ZA, Espino OJ. Gliosarcoma de fosa posterior. Arch Neurocien (Mex) 2006; 11, 2: 136-140,.
Boerman RH, Anderl K, Herath J. The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol 1996; 55: 973-981.
Kleihues P, Burger PC, Scheithauer BW: The new WHO classification of brain tumours. Brain Pathol 1993, 3: 255–268.
Biernat W, Hegi M, Aguzzi A, Kleihues P: Gliosarcoma: Pathology and Genetics of Tumours of the Nervous System. Edited by P Kleihues, WKCavenee. Lyon, International Agency for Research on Cancer, 1997, 27–28.
Han SJ, Yang I, Tihan T, Prados MD, Parsa AT. Primary gliosarcoma: Key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. J Neurooncol 2010; 96: 313- 320,.
Lutterbach J, Guttenberger R, Pagenstecher A (2001) Gliosarcoma: a clinical study. Radiother Oncol 61:57–64.
Lee Y, Castillo M, Nauert C, Moser RP. Computed tomography of gliosarcoma. Am J Neuroradiol 1985; 4: 527–531.
Maiuri F, Stella L, Benvenuti D, Giamundo A, Pettinato G. Cerebral gliosarcomas: correlation of computed tomographic findings, surgical aspect, pathological features, and prognosis. Neurosurgery 1990; 26: 261–267.
Beaumont T, Kupsky WJ, Barger GR, Sloan AE. Glioblastoma with multiple extracranial metastases: case report and review of literature. J Neurooncol 2007; 83: 39–46.
Hsieh JK, et al. An IDH1-mutated Primary gliosarcoma: case report. J Neurosurg. 2016; 1-5.
Romeike BFM, Chen Y, Walter J, Petersen I: Diagnostic util- ity of IDH1- and p53-mutation analysis in secondary gliosar- coma. Clin Neuropathol 2011; 30: 231–234.
Vajtai I, Vassella E, Hewer E, Kappeler A, Reinert MM: Sar- comatous evolution of oligodendroglioma (“oligosarcoma”): confirmatory report of an uncommon pattern of malignant progression in oligodendroglial tumors. Pathol Res Pract 2012; 208: 750–755.
Lee D, Kang SY, Suh YL, Jeong JY, Lee JI, Nam DH: Clini- copathologic and genomic features of gliosarcomas. J Neurooncol 2012; 107:643–650.
Hiniker A, Hagenkord JM, Powers MP, Aghi MK, Prados MD, Perry A: Gliosarcoma arising from an oligodendroglioma (oligosarcoma). Clin Neuropathol 2013; 32:165–170.
Joseph NM, Phillips J, Dahiya S, M Felicella M, Tihan T, Brat DJ, et al: Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. Mod Pathol 2013; 26:315–326.
Codispoti KET, Mosier S, Ramsey R, Lin MT, Rodriguez FJ: Genetic and pathologic evolution of early secondary gliosarcoma. Brain Tumor Pathol 2014; 31: 40–46.
Hinojosa AQ, Kosztowski T, Brem H. Malignant Gliomas: Anaplastic Astrocytoma, Glioblastoma Multiforme, Gliosarcoma. In Youmans JR, editors. Neurological Surgery. Philadelphia: WB Saunders; 2011:1327-1340.
E. E. Pakos, A. C. Goussia, E. J. Pitouli, and P. G. Tsekeris, Primary cerebral gliosarcoma: a case presentation with review of the literature. Journal of B.U.ON., 2004; 9, 4: 481–484.
M. Salvati, E. Caroli, A. Raco, F. Giangaspero, R. Delfini, and L. Ferrante, “Gliosarcomas: analysis of 11 cases do two subtypes exist?” Journal of Neuro- Oncology 2005; 74, 1: 59–63,.
Martin J, Devadoss P, Kannan k, Sundarraj SK. Malignant Pediatric Gliosarcoma Defies General Survival Data. Case Reports in Medicine 2014; 1-5.
Han SJ, Yang I, Tihan T, Chang SM, Parsa AT. Secondary gliosarcoma: a review of clinical features and pathological diagnosis. J Neurosurg 2010; 112: 26-32.
Meena US, Sharma S, Chopra S, Jain SK. Gliosarcoma: A rare variant of glioblastoma multiforme in paediatric patient: Case report and review of literatura. World J Clin Cases 2016; 16; 4(9): 302-305,.