medigraphic.com
ISSN 1405-1699 (Print)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2019, Number 1

<< Back

Alerg Asma Inmunol Pediatr 2019; 28 (1)

Vitamina D y su papel en el sistema inmune

Ramírez SE, Pedroza MÁ

Language: Spanish
References: 41
Page: 26-34
PDF size: 224.88 Kb.


ABSTRACT

When it was catalogued as a vitamin and classified as a dispensable nutrient, its function was left for a limited time to the bone metabolism and its associated diseases at that level, however, at the beginning of this century, the genomic activity in which vitamin D was related was described, as well as the direct and rapid effects it caused at the molecular level, modifying cellular responses in different fields and in different metabolic steps, so it was observed its effect as a context at the cellular level and now as a cause of disease as such, so it has motivated its study in different diseases to different organs and systems, so now there is a review of its role on health and disease in the immune system. And we also describe how difficult it is to obtain from the daily intake, as well as to describe the most current recommended doses in their deficiency and in a disease.


REFERENCES

  1. Kaufer-Horwitz M, Pérez-Lizaur AB, Arroyo P. Nutriología médica. Capítulo 3. 4a edición. Ed. Panamericana; 2015. pp. 40-60.

  2. Holick MF, MacLaughlin JA, Clark MB, Holick SA, Potts JT Jr, Anderson RR et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science. 1980; 210 (4466): 203-205.

  3. Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am. 2010; 39 (2): 243-253.

  4. Morris HA, Anderson PH. Autocrine and paracrine actions of vitamin D. Clin Biochem Rev. 2010; 31 (1): 129-138.

  5. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009; 94 (1): 26-34.

  6. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008; 88 (2): 491S-499S.

  7. Pike JW, Meyer MB. The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinol Metab Clin North Am. 2010; 39 (2): 255-269.

  8. Mizwicki MT, Norma AW. The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling. Sci Signal. 2009; 2 (75): re4.

  9. Trochoutsou AI, Kloukina V, Samitas K, Xanthou G. Vitamin-D in the immune system: genomic and non-genomic actions. Mini Rev Med Chem. 2015; 15 (11): 953-963.

  10. Liu PT, Stenger S, Li H, Wenzel L et al. Toll like receptor triggering of a vitamin D-mediated human antimicrobial responce. Science. 2006; 311 (5768): 1770-1773.

  11. Castrillo RL, Palma RA, Padilla DC. Péptidos antimicrobianos: antibióticos naturales de la piel. Dermatología Rev Mex. 2007; 51 (2): 57-67.

  12. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005; 19 (9): 1067-1077.

  13. Bouvard B, Annweiler C, Sallé A, Beauchet O, Chappard D, Audran M et al. Extraskeletal effects of vitamin D: facts, uncertainties, and controversies. Joint Bone Spine. 2011; 78 (1): 10-16.

  14. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012; 188 (5): 2127-2135.

  15. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010; 39 (2): 365-379.

  16. Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M et al. Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol. 2010; 30 (12): 2495-2503.

  17. Hewison M, Zehnder D, Chakraverty R, Adams JS. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 2004; 215 (1-2): 31-38.

  18. Matsui T, Nakao Y, Koizumi T, Nakagawa T, Fujita T. 1,25- Dihydroxyvitamin D3 regulates proliferation of activated T-lymphocyte subsets. Life Sci. 1985; 37: 95-101.

  19. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O’Garra A. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol. 2001; 167 (9): 4974-4980.

  20. Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther. 2008; 324 (1): 23-33.

  21. Cantorna MT, Hullett DA, Redaelli C, Brandt CR, Humpal-Winter J, Sollinger HW et al. 1,25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density. Transplantation. 1998; 66 (7): 828-831.

  22. Merrill SJ, Minucci SB. Thyroid Autoimmunity: an interplay of factors. Vitam Horm. 2018; 106: 129-145.

  23. Bagot M, Charue D, Lescs MC, Pamphile RP, Revuz J. Immunosuppressive effects of 1,25-dihydroxyvitamin D3 and its analogue calcipotriol on epidermal cells. Br J Dermatol. 1994; 130 (4): 424-431.

  24. Khosravi-Largani M, Pourvali-Talatappeh P, Rousta AM, Karimi-Kivi M, Noroozi E, Mahjoob A et al. A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis. eNeurologicalSci. 2018; 10: 37-44.

  25. Vasquez AD. La vitamina D y su importancia en la salud humana. Medicina. 2013; 35 (3): 214-226.

  26. Zuluaga ENA, Alfaro VJM, Balthazar GV, Jiménez BKE, Campuzano MG. Vitamina D: nuevos paradigmas. Medicina & Laboratorio. 2011; 17 (05-06): 211-246.

  27. Correale J, Ysrraelit MC, Gaitán MI. Efectos inmunomoduladores de la vitamina d en esclerosis múltiple. Neurología Argentina. 2009; 1 (2): 82-94.

  28. Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012; 185 (2): 124-132.

  29. Demir MG. Comparison of 1α-25-dihydroxyvitamin D3 and IgE levels between allergic rhinitis patients and healthy people. Int Arch Otorhinolaryngol. 2018; 22 (4): 428-431.

  30. Sadat-Ali M, Al-Anii FM, Al-Turki HA, AlBadran AA, AlShammari SM. Maintenance dose of vitamin d: how much is enough? J Bone Metab. 2018; 25 (3): 161-164.

  31. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357 (3): 266-281.

  32. Diehl JW, Chiu MW. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatol Ther. 2010; 23 (1): 48-60.

  33. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M; Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008; 122 (2): 398-417.

  34. Boskabadi H, Zakerihamidi M, Faramarzi R. The vitamin D level in umbilical cord blood in premature infants with or without intra-ventricular hemorrhage: A cross-sectional study. Int J Reprod Biomed (Yazd). 2018; 16 (7): 429-434.

  35. Grossman Z, Hadjipanayis A, Stiris T, Del Torso S, Mercier JC, Valiulis A et al. Vitamin D in European children-statement from the European Academy of Paediatrics (EAP). Eur J Pediatr. 2017; 176 (6): 829-831.

  36. Ongaratto R, Rosa KMD, Eloi JC, Epifanio M, Marostica P, Pinto LA. Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis. Einstein (Sao Paulo). 2018; 16 (1): eAO4143.

  37. Weiler H, Fitzpatrick-Wong S, Veitch R, Kovacs H, Schellenberg J, McCloy U et al. Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ. 2005; 172 (6): 757-761.

  38. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96 (7): 1911-1930.

  39. Farraye FA, Nimitphong H, Stucchi A, Dendrinos K, Boulanger AB, Vijjeswarapu A et al. Use of a novel vitamin D bioavailability test demonstrates that vitamin D absorption is decreased in patients with quiescent Crohn’s disease. Inflamm Bowel Dis. 2011; 17 (10): 2116-2121.

  40. Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Curr Opin Gastroenterol. 2012; 28 (2): 139-150.

  41. Mendoza-Zubieta V, Reza-Albarrán AA. Vitamina D: Más allá del tratamiento de las enfermedades óseas. Rev Endocrinol Nutr. 2009; 17 (1): 4-6.




2020     |     www.medigraphic.com