2006, Number 3
<< Back Next >>
Cir Cir 2006; 74 (3)
Frequency of heart tumors and their histopathological correlation
Villalpando-Mendoza E, Pérez-Pérez FM, Cortés-Flores AO, Velázquez-Ramírez GA, Fuentes-Orozco C, González-Ojeda A
Language: Spanish
References: 23
Page: 183-187
PDF size: 82.71 Kb.
ABSTRACT
Background: The presentation of heart tumors is very
uncommon. Eighty percent of primary heart neoplasias are benign, and myxomas represent the first cause in frequency among adult populations. Due to the frequency of presentation of these tumors, it is common to make the clinical/surgical diagnosis without obtaining histopathologic confirmation. Our objective was to determine the frequency of presentation of heart tumors and its correlation between the surgical/clinical and histopathologic diagnosis in our Institute.
Methods: This is a case series with 16 patients with cardiac tumors treated surgically at the Department of Cardiothoracic Surgery during a 4-year period. We used descriptive statistics, and quantitative variables are expressed as mean, range and standard deviation whereas qualitative variables were described as proportions.
Results: We included 3 men (19 %) and 13 women (81 %) with a mean age of 41.4 ± 16.2 years. Clinical presentation was predominantly of congestive heart failure. Clinical diagnosis was determined in 15 patients (94 %) and just one case of intracardiac thrombus (6 %), whereas the histopathologic diagnosis reported myxoma in only 11 cases (68.8 %), three patients with intra-cardiac thrombus (18.7 %) and two patients with sarcomas (12.5 %), leiomiosarcoma and angiosarcoma, respectively. We found a positive correlation between the clinical diagnosis and the histopathology results. There was no mortality.
Conclusions: Even though myxomas represent the most
frequent proportion of presentation in heart tumors, histopathological confirmation is necessary for diagnosis. Clinical and histopathologic correlation represents the basis for the choice of adequate management strategies and prognosis for the patient.
REFERENCES
1.Ackerman J, McKeown P, Gunasekaran S, Spice D. Pathological case of the month. Cardiac fibroma. Arch Pediatr Adolesc Med 1995;149:199-200.
2.Casha AR, Davidson LA, Roberts P, Nair RU. Familial angiosarcoma of the heart. J Thorac Cardiovasc Surg 2002;124:392-394.
3.Sutton GC, Chatterjee K. Cardiac Tumors. Clinical Cardiology. An Illustrated Text, 1st ed. London: Atlas Medical Publishing Ltd;2002. pp. 373-388.
4.Vaughan CJ, Veugelers M, Basson CT. Tumors and the heart: molecular genetic advances. Curr Opin Cardiol 2001;16:195-200.
5.Burke A, Virmani R. Tumors of the heart and great vessels. In: Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology;1996. p. 36.
6.Beghetti M, Gow RM, Haney I, Mawson J, Williams WG, Freedom RM. Pediatric primary benign cardiac tumors: a 15-year review. Am Heart J 1997;134:1107-1114.
7.Beloosesky Y, Katz M, Grinblat J. Giant incidental cardiac mass compatible with myxoma in a 92-year-old woman. J Am Geriatr Soc 2001;49:233-234.
8.Fyke FE, Seqard JB, Edwards WD, Miller FA, Reeder GS, Schattenberg TT, et al. Primary cardiac tumors: experience with 30 consecutive patients since the introduction of two-dimensional echocardiography. J Am Coll Cardiol 1985;5: 1465-1473.
9.Quijano-Pitman F, Carrillo J, Mendoza F. Mixoma de la aurícula izquierda. Informe del primer caso operado con éxito en México. Arch Inst Cardiol Mex 1967;37:541-545.
10.Kang N, Hughes CF. Massive pulmonary embolus complicating left atrial myxoma. J Thorac Cardiovasc Surg 2001;121:814-815.
11.Centella T, Oliva E, García-Andrade I, Lamas MJ, Epeldegui A. Angiosarcoma cardiaco. Cuatro años de supervivencia. Revisión a propósito de un caso. Rev Esp Cardiol 2005;58:310-312.
12.Chachques JC, Argyriadis PG, Latremouille C, D’Attellis N, Fornes P, Bruneval P, et al. Cardiomyoplasty: ventricular reconstruction after tumor resection. J Thorac Cardiovasc Surg 2002;123:889-894.
13.Barnes AR, Beaver DC, Snell AM. Primary sarcoma of the heart: report of a case with electrocardiographic and pathologic studies. Am Heart J 1934;9:480.
14.Piazza N, Chunghtai T, Toledano K, Sampalis J, Liao C, Morin JF. Primary cardiac tumours: eighteen years of surgical experience on 21 patients. Can J Cardiol 2004;20:1443-1448.
15.Alfaro-Gómez F, Careaga-Reyna G, Valero-Elizondo G, Argüero-Sánchez R. Tumores cardíacos. Experiencia de 16 años en el Hospital de Cardiología del Centro Médico Nacional Siglo XXI. Cir Ciruj 2003;71:179-185.
16.Scott N, Veinot JP, Chan KL. Symptoms in cardiac myxoma. Chest 2003;124:2408.
17.Shapiro LM. Cardiac tumors: diagnosis and management. Heart 2001;85:218-222.
18.Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F. Histopathologic and clinical characterization of cardiac myxoma: review of 53 cases from a single institution. Am Heart J 2000;140: 134-138.
19.Basso C, Bottio T, Valente M, Bonato R, Casarotto D, Thiene G. Primary cardiac valve tumours. Heart 2003;89:1259-1260.
20.Sarjeant JM, Butany J, Cusimano RJ. Cancer of the heart: epidemiology and management of primary tumors and metastases. Am J Cardiovasc Drugs 2003;3:407-421.
21.Percell RL, Henning RJ, Siddique Patel M. Atrial myxoma: case report and a review of the literature. Heart Dis 2003;5:224-230.
22.Restrepo CS, Largoza A, Lemos DF, Diethelm L, Koshy P, Castillo P, et al. CT and MR imaging findings of benign cardiac tumors. Curr Probl Diagn Radiol 2005;34:12-21.
23.Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumors: diagnosis and management. Lancet Oncol 2005;6:219-228.