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2006, Number 1

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Bioquimia 2006; 31 (1)

Human leukocyte antigens class II and hepatitis C virus infection

Martínez-Córdova Z, Brito-García A, Piedra-Mazorra MJ, Trujillo-Álvarez Y, Bonet-Roselló L, Peña-Fresneda N, Vigueras-López R

Language: Spanish
References: 90
Page: 23-33
PDF size: 102.55 Kb.


ABSTRACT

Hepatitis C virus (HCV) persists in the majority of infected individuals and is responsible for a wide spectrum of chronic liver lesions ranging from minimal inflammation to cirrhosis or hepatocellular carcinoma. Differences in the immunogenetic backgrounds of infected patients might in part account for the observed variation in the individual courses of the disease. A genetically determined resistance or susceptibility to chronic hepatitis C virus infection make an important contribution to the course of liver disease and may be linked to the Human Major Histocompatibility Complex (MHC). Several studies have aimed to identify human leukocyte antigens (HLA) class II alleles associated with different outcomes of HCV infection. The aim of this review is to make a differentiation between the effects of some MHC class II alleles in the host response to HCV infection. We found in the consulted literature alleles like DRB1*11, DQB1*0301 and DRB1*0101 with a protective role in the outcome, clearance of the HCV infection and response to treatment and DQB1*02, DRB1*0701 alleles with harmful effects in HCV infected patients. The study of the role MHC class II alleles in the outcome and clearance of HCV infection is important in understanding the immune-virus specific response in the host and it will improve the development of effective vaccines and antiviral therapies.


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