2018, Number 3
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Arch Neurocien 2018; 23 (3)
Bevacizumab with adjuvant cyclophosphamide metronomical dose an alternative therapy in patients with recurrent gliomas
Briceño ED, Naranjo-Gomez AL
Language: Spanish
References: 26
Page: 19-27
PDF size: 650.68 Kb.
ABSTRACT
Recurrent glioblastoma is a common problem faced by neurologists, neuro-oncologists,
neuroradiologists and neurosurgeons due to the poor response to therapy schemes. We
present a series of cases of 15 patients with recurrent glioblastoma diagnosis without surgical
and / or radiotherapeutic interventions, patients with aged between 18 and 75 years (average
of 55 years) treated with combined therapy bevacizumab and cyclophosphamide after
refractoriness to other treatment regimens. Chemotherapy, during the follow-up period was
observed a progression-free time between 6-21 months, average of 9 months and survival
of 9.3 months with a low degree of toxicity during follow-up considering this scheme as an
alternative therapeutic option
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