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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2006, Number 2

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An Med Asoc Med Hosp ABC 2006; 51 (2)

Expression of p161NK4a in biopsies of the uterine cervix. Utility in the differential diagnosis between chronic reactive cervicitis, low and high grade cervical intraepithelial neoplasm and invasive carcinoma

Canedo PAM, Alcántara VA, Ortiz HC

Language: Spanish
References: 17
Page: 49-57
PDF size: 186.87 Kb.


ABSTRACT

Morbimortality of carcinoma of the uterine cervix has been reduced by cytological screening, which detects early lesions. However false negative and positive rates for cervical premalignant lesions and problems with intra and interobserver reproducibility in histological diagnosis of cervical intraepithelial neoplasia have forced to investigation objective markers for identifying dysplastic cells. p16INK4a is a product of gen p16, useful for distinguishing cervical neoplastic lesions from reactive cells. We studied 65 biopsies of uterine cervix with diagnosis of reactive cervix in six cases, low grade intraepithelial lesion in fifteen, high grade intraepithelial lesion in twenty eight (15 NIC II and 13 NIC III), in situ carcinoma in two and invasive carcinoma in fourteen. Our results showed a direct relationship between the immunohistochemical over expression of p16INK4a and the grade of the neoplasic lesion. Ninety two percent (92%) of invasive carcinomas, 100% of in situ carcinomas and 100% of high-grade intraepithelial lesion (NIC III) showed positivity for p16. All the reactive cervices were negative for p16. Of the group of the low-grade intraepithelial lesions, only 33.33% were positives for p16. Our results confirm the utility of the p16INK4a for distinguishing reactive from intraepithelial lesions of the uterine cervix.


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