Canedo PAM, Alcántara VA, Ortiz HC

Idioma: Español
Referencias bibliográficas: 17
Paginas: 49-57
Archivo PDF: 186.87 Kb.

RESUMEN

La morbimortalidad por carcinoma de cérvix uterino ha disminuido gracias a la citología cervicovaginal que detecta lesiones cervicales tempranas. Sin embargo, el índice de falsos positivos y negativos, así como la falta de reproducibilidad intra e interobservador en el diagnóstico de neoplasia intraepitelial cervical han llevado a investigar marcadores objetivos para la identificación de células displásicas. p16INK4a es un producto del gen p16, que ha demostrado ser útil en distinguir células neoplásicas de células reactivas. Estudiamos 65 biopsias de cérvix con diagnósticos de cervicitis crónica en seis, lesión intraepitelial de bajo grado en 15, lesión intraepitelial de alto grado en 28 (15 NIC II y 13 NIC III), carcinoma epidermoide in situ en dos y carcinoma invasor en 14. Nuestros resultados demostraron relación directa entre la sobreexpresión de p16INK4a mediante inmunohistoquímica, y el grado de lesión neoplásica. Novena y dos por ciento de carcinomas invasores, 100% de carcinomas in situ y 100% de lesiones intraepiteliales de alto grado expresaron p16. Todos los cérvix reactivos fueron negativos al p16. Del grupo de lesiones intraepiteliales cervicales de bajo grado, sólo 33.33% fueron positivas a p16. Estos hallazgos confirman la utilidad de p16INK4a para distinguir cérvix reactivo de lesiones intraepiteliales de alto grado.

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