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2018, Number 4

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Rev Hematol Mex 2018; 19 (4)

Translocations in acute lymphoblastic leukemia and five year-survival in children

Chargoy-Vivaldo E, Martínez-Hernández C, Cacique-Sánchez C, Jimaréz- Rodríguez JM, Gómez-Cárdenas L

Language: Spanish
References: 29
Page: 165-173
PDF size: 337.66 Kb.


ABSTRACT

Background: Five-year disease-free survival in acute lymphoblastic leukemia (ALL) is greater than 80% in developed countries; in Oaxaca a lower survival is observed. It is important to know the epidemiology of translocations associated with poor prognosis and the results of the treatments used.
Objective: To determine the 5-year survival of pediatric patients diagnosed with acute lymphoblastic leukemia according to the treatment prescribed in two hospitals of Oaxaca, Mexico.
Material and Method: A descriptive, observational, analytical and retrospective study was done. All clinical files of patients diagnosed with acute lymphoblastic leukemia in the Hospital Presidente Juárez, ISSSTE, and in the Hospital de la Niñez Oaxaqueña Dr. Guillermo Zarate Mijangos, Oaxaca, from January 2010 to December 2015 were analyzed.
Results: Survival at 5 years with Total XV and with the national protocol was 66.6% and 64.2%, respectively. The translocations found were 9:22, 1:19, 12:21, 8:21 and 6:11.
Conclusions: The most frequent translocations in Oaxaca patients were: t(9:22) and t(1:19); however, they do not impact on global survival. Pediatric population in Oaxaca has more leukemias with a poor prognosis.


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