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ISSN 2007-3194 (Print)
Órgano de difusión oficial del Instituto Materno Infantil del Estado de México

2018, Number 2

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Arch Inv Mat Inf 2018; 9 (2)

Hepatitis secondary to perinatal cytomegalovirus infection. Case report and literature review

Mejía CLB, Rincón ZJ

Language: Spanish
References: 14
Page: 64-69
PDF size: 122.12 Kb.


ABSTRACT

We present the case of a 2-month-old male patient who came to our institution for jaundice, acolia and coluria. At admission with elevation of bilirubins and liver enzymes more than 3 times the normal value, with cholestatic pattern. During internment with search of infectious, metabolic and anatomical causes; serology and positive polymerase chain reaction were reported for cytomegalovirus so treatment with ganciclovir was decided. Cytomegalovirus infection is asymptomatic in most cases, however in some cases it can present with affection to a target organ, including the liver. In the literature there are currently only reports of series of cases with liver involvement, without standardized treatment guidelines for this group of patients. The evidence of the effectiveness of the treatment is scanty and controversial. In this case, treatment with ganciclovir was decided due to the severity of the hepatitis and to try to avoid chronic complications such as liver cirrhosis. He presented clinical and paraclinical improvement from the beginning of treatment, without complications and without relapses. Although each case must be individualized, treatment with ganciclovir shows good response without causing adverse effects during its administration.


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