Soler NG, Aquino RS, Bencomo HA, Sosa GLC

Language: Spanish
References: 0
Page: 84-94
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ABSTRACT

Introduction: Neonatal alloimmune thrombocytopenia (NAIT) is produced by action of a maternal antiplatelet alloantibody, which reacts with an antigen on fetal/neonatal platelets, inherited from the father, causing severe thrombocytopenia and hemorrhagic diathesis.
Objective: To determine the number of infants diagnosed with NAIT and its relationship with clinical symptoms, platelet count, complications, lethality and treatment.
Methods: A longitudinal, retrospective, descriptive and observational study in all maternity hospitals in Havana, during 5 years, was carried out. The data were analyzed using the statistical package MICROSTA, contingency tables were performed, calculation of fees, rates and nonparametric Chi Square test significance level of 0.05.
Results: The incidence in the period was 1 x every 13 869 live births, with lethality of 33.3 % and a proportional mortality rate was 5.95 per 1 000 live births. No association between complications and some prenatal background and platelet counts was found. We found significance of the use of red packed cells and IgGev in complicated patients (p= 0.0201). 88.9 % of cases showed clinical manifestations in the firsh hour of birth.
Conclusions: The rate of NAIT found in Havana was much lower than reported in other countries, with high case fatality and proportional mortality rates. The onset of clinical manifestations was early, deaths occurred before 12 hours of births.