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2001, Number 2

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Rev Endocrinol Nutr 2001; 9 (2)

Obstructive sleep apnea in obese patients

Valencia-Flores M, Rebollar GV, Orea TA, Castaño-Meneses A, García-Ramos G, González-Barranco J

Language: Spanish
References: 44
Page: 97-102
PDF size: 158.02 Kb.


ABSTRACT

In normal organisms sleep is usually a time of minimal stress. In many obese patients, sleep could be stressful, impairs the quality of daytime life, and distorts normal physiology of the body sufficiently to even cause death. The more prevalent sleep disorders in obese subjects are abnormalities in the respiratory function such as snoring, obstructive sleep apnea syndrome (OSAS) and alveolar hypoventilation or a combination of these. Ninety eight percent of the morbidly obese patients followed at the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (INCMNSZ) have OSAS and 60% of those also have alveolar hypoventilation. We identified neck circumference (cm) as the anthropometrical measure associated with severity of the apnea. Patients with a neck circumference of 47 cm had 65 apnea episodes per hour of sleep, blood oxygen saturation less than 65% and an increased frequency of cardiac arrhythmias. Chronic OSAS (>10 years) associated with nocturnal hypoxemia and hypercapnia could lead to an attenuation of the hypoxic and hypercapnic ventilatory drives during wakefulness and can be associated with pulmonary hypertension. Effective therapeutic regimens should be addressed at obesity, obstructive sleep apnea and decreased ventilatory drive.


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