2001, Número 2
<< Anterior Siguiente >>
Rev Endocrinol Nutr 2001; 9 (2)
Apnea del sueño en el paciente obeso
Valencia-Flores M, Rebollar GV, Orea TA, Castaño-Meneses A, García-Ramos G, González-Barranco J
Idioma: Español
Referencias bibliográficas: 44
Paginas: 97-102
Archivo PDF: 158.02 Kb.
RESUMEN
El dormir puede representar en el paciente obeso, un período de estrés, el cual puede tener un impacto negativo sobre la vida diurna del paciente y en algunos casos, puede relacionarse con la muerte. Los trastornos del dormir más comunes en el obeso son las alteraciones en la respiración durante el sueño, las cuales pueden ser: Roncopatía, síndrome de apnea obstructiva de sueño (SAOS) e hipoventilación alveolar o una combinación de ellas. El 98% de los pacientes obesos mórbidos que acuden al Instituto Nacional de Ciencias Médicas y Nutrición “Dr. Salvador Zubirán” (INCMNSZ) presentan síndrome de apnea obstructiva de sueño y de ellos, el 60% presenta además hipoventilación alveolar. En la población de obesos, el indicador antropométrico que se asocia con la gravedad de la apnea, es la circunferencia del cuello. Los pacientes obesos con una circunferencia de cuello de 47 ó más centímetros, presentan índices de alteraciones en la respiración durante el sueño superiores o iguales a 65 eventos por hora de sueño, con saturaciones de oxígeno en sangre < 65%, y mayor frecuencia de arritmias cardíacas. La cronicidad de la apnea de sueño (10 ó mas años) acompañada de episodios repetidos de hipoxia e hipercapnia puede dar lugar a disminución en la respuesta ventilatoria ante la hipoxia y la hipercapnia diurna y esta alteración en los gases puede asociarse con hipertensión pulmonar. Los regímenes terapéuticos de mayor éxito son los que se dirigen a la reducción del peso corporal, eliminación de la apnea obstructiva de sueño y aumento del impulso ventilatorio.
REFERENCIAS (EN ESTE ARTÍCULO)
Lugaresi E, Cirignotta F, Montagna P, Sforza E. Snoring: pathogenic, clinical and therapeutic aspects. En: Kryger MH, Roth T, Dement WC, Eds. Principles and Practice of Sleep Medicine. Philadelphia: W.B.Saunders Co.1994: 621-629.
Metes A, Ohki M, Cole P, Haight JS, Hoffstein V. Snoring, apnea and nasal resistance in men and women. J Otolaryngol 1991; 20:57-61.
Lugaresi E, Cirignotta F, Coccagna G. Heavy snorers disease. En: Karczewski WA, Grieb P, Kulesza J, eds. Control of Breathing During Sleep and Anesthesia. New York: Plenum Press 1988: 5-18.
Chi-Lem G. Ronquidos. Significancia clínica, mecanismo de producción, alternativas diagnósticas y tratamiento. En: Valencia-Flores M, Salín-Pascual R, Perez-Padilla R. Trastornos del dormir. México:McGraw-Hill Interamericana 2000:317-329.
Hudgel DW. Clinical manifestations of the sleep apnea syndrome. En: Fletcher EC, ed. Abnormalities of Respiration During Sleep. Orlando: Grune &Stratton, 1986:21-37.
Lugaresi E, Cirignotta F, Montagna P. Clinical approach to heavy snorers disease and other sleep related respiratory disorders. En: Peter JH, Podszus T, von Wichert P, eds. Sleep Related Disorders and Internal Diseases. Berlin: Springer-Verlag 1987:201-210.
Mondini S, Zucconi M, Cirignotta F. Snoring as a risk factor for cardiac and circulatory problems: an epidemiological study. En: Guilleminault C, Lugaresi E, eds. Sleep/Wake Disorders: natural history, epidemiology, and long-term evolution. New York: Raven Press 1983: 99-105.
Lyons HA, Huang CT. Therapeutic use of progesterone in alveolar hypoventilation associated with obesity. Am J Med 1968; 44:881-888.
Maislin G, Pack AI, Kribbs NB, Smith PL, Schwartz AR, Kline LR, Schwab RJ, Dinges DF. A survey screen for prediction of apnea. Sleep, 1995;18:158-166.
Valencia-Flores M, Orea A, Castaño VA, Resendiz M, Rosales M, Rebollar V, Santiago V, Gallegos J, Campos RM, González J, Oseguera J, García-Ramos G, Bliwise DL. Prevalence of sleep apnea and electrocardiographic disturbances in morbidly obese patients. Obesity Res 2000; 8:262-269.
American Academy of Sleep Medicine. Sleep-related breathing disorders in adults: recomendations for syndrome definitions and measurement techniques in clinical research. Sleep 1999; 22:667-689.
Hoffstein V, Zamel N, Phillipson EA. Lung volume dependence of pharyngeal cross-sectional area in patients with obstructive sleep apnea. Am Rev Respir Dis 1984; 130:175-178.
Bradley TD, Brown IG, Grossman R. Pharyngel size in snorers, non-snorers, and patients with obstructive sleep apnea. N Engl J Med 1986; 315:1327-1331.
Koening J, Thach B. Effects of mass loading on the upper airway. J Appl Physiol 1988;64:2294-2299.
Davies RJO, Stradling JR. The relationship between neck circumference, radiographic pharyngeal anatomy, and the obstructive sleep apnea syndrome. Eur Respir J 1990; 3:509-514
Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 1983; 52:490-494.
Shepard JW, Garrison MW, Grither DA, Dolan GF. Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest 1985; 88:335-340.
Flemons WW, Remmers JE, Gillis AM. Sleep apnea and cardiac arrhythmias is there a relationship? Am Rev Respir Dis 1993; 148:618-621.
Kimoff RJ, Cosio MG, McGregor M. Clinical features and treatment of obstructive sleep apnea. Can Med Assoc J 1991; 144:689-695.
Lavie P, Ben-Yosef R, Rubin AE. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J 1984; 108:373-376.
Fletcher EC, DeBehnke RD, Lovoi MS, Gorin AB. Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 1985; 103:190-195.
Weitzenblum E, Krieger J, Apprill M, Vallée E, Ehrhart M, Ratomaharo J, Oswald M, Kurtz D. Daytime pulmonary hypertension in patients with obstructive sleep apnea syndrome. Am Rev Respir Dis 1988; 138:345-349.
Sajkov D, Cowie RJ, Thornton AT, Espinoza HA, McEvoy RD. Pulmonary hypertension and hypoxemia in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 1994; 149:416-422.
Laks L, Lehrhaft B, Grunstein RR, Sullivan CE. Pulmonary hypertension in obstructive sleep apnoea. Eur Respir J 1995;8:537-541.
Chaouat A, Weitzenblum E, Krieger J, Oswald M, Kessler R. Pulmonary hemodynamics in the obstructive sleep apnea syndrome. Results in 220 consecutive patients. Chest 1996; 109:380-386.
Krieger J, Sforza E, Apprill M, Lampert E, Weitzenblum E, Ratomaharo J. Pulmonary hipertensión, hypoxemia, and hypercapnia in obstructive sep apnea patients. Chest 1989; 96:729-737.
Fletcher EC, Schaaf JM, Miller J, Fletcher JG. Long-term cardiopulmonary sequelae in patients with sleep apnea and chronic lung disease. Am Rev Respir Dis 1987; 135:525-533.
Rochester DF, Enson Y. Current concepts in the pathogenesis of the obesity-hypoventilation syndrome. Mechanical and circulatory factors. Am J Med 1974; 57:402-420.
Zwillich CW, Sutton FD, Pierson DJ, Creagh EM, Weil JV. Decreased hypoxic ventilatory drive in the obesity-hypoventilation syndrome. Am J Med 1975; 59:343-348.
Lourenco RV. Diaphragm activity in obesity. J Clin Invest 1969; 48:1609-1614.
Sharp JT, Druz WS, Kondragunta VR. Diaphragmatic responses to body position changes in obese patients with obstructive sleep apnea. Am Rev Respir Dis 1986; 133:32-37.
Thomas PS, Cowen ERT, Hulands G, Milledge JS. Respiratory function in the morbidly obese before and after weight loss. Thorax 1989; 44:382-386.
Krachman S, Criner GJ. Hypoventilation syndromes. Clin Chest Med 1998; 19:139-155.
Burwell CS, Robin ED, Whaley RD, Bickelman AG. Extreme obesity associated with alveolar hypoventilation- A Pickwickian syndrome. Am J Med 1956; 21:811-818
Cullen JH, Formel PF. The respiratory defects in extreme obesity. Am J Med 1962; 32:525-531
Milic-Emili J, Tyler JM. Relation between work output of respiratory muscles and end-tidal CO2 tension. J Appl Physiol 1963; 18:497.
Doell D, Zutter M. Anthonisen NR. Ventilatory responses to hypercapnia and hypoxia at 1 and 4 ATA. Respir Physiol 1973; 18:338.
Weil JV, Byrne-Quinn E, Sodal IE, Filley GF, Grover RF. Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J Clin Inv 1971; 50:186-195.
Jones JB, Wilhoit SC, Findley LJ, Suratt PM. Oxyhemoglobin saturation during sleep in subjects with and without the obesity-hypoventilation syndrome. Chest 1985; 88:9-15.
Sullivan CE, Issa FG, Berthon-Jones M, Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet 1981; 1:862-865.
Sanders MH, Moore SE, Eveslage J. CPAP via nasal mask a treatment for occlusive sleep apnea. Chest 1983; 83:144-145.
Remmers JE, Sterling JA, Thorarinsson B, Kuna ST. Nasal airway positive pressure in patients with occlusive sleep apnea. Am Rev Respir Dis 1984; 130:1152-1155.
McEvoy RD, Thornton AT. Treatment of obstructive sleep apnea syndrome with nasal continuous positive airway pressure. Sleep 1984; 7:313-325.
Sforza E, Krieger J, Weitzenblum E, Apprill M, Lampert E, Ratamaharo J. Long-term effects of treatment with nasal continuous positive airway pressure on daytime lung function and pulmonary hemodynamics in patients with obstructive sleep apnea. Am Rev Respir Dis 1990; 141:866-870.