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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2017, Number 3

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Rev Esp Med Quir 2017; 22 (3)

Impact of management of vitamin C in the prognosis of patients with septic shock and severe sepsis

Torres-Valdez S, Ramírez-Campaña J, Vázquez-Rodríguez JG, López A, Soto-Acevedo F, López-Morales CM

Language: Spanish
References: 23
Page: 87-94
PDF size: 1040.02 Kb.


ABSTRACT

Background: The high extent of oxidative stress in patients with severe sepsis and septic shock produces significant depletion of endogenous antioxidants such as vitamin C. Evidence suggests that administration of this antioxidant reduces infectious complications and organ dysfunction, morbidity and mortality. The objective of the study was to evaluate the impact of the administration of vitamin C in prognosis of patients with severe sepsis and septic shock.
Material and Methods: Case-control study was conducted in an emergency department and metabolic polyvalent intensive care unit, with a consecutive sample of 100 records of patients diagnosed with severe sepsis and/or septic shock. The control group consists of 72 cases diagnosed with severe sepsis and/or septic shock hospitalized for at least three days, the study group included 23 records of patients with the same diagnosis which had received 3 g of vitamin C in 24 h on three consecutive days as part of their treatment. The main variables were severe sepsis, septic shock, vitamin C, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, morbidity, mortality, and hospital stay days.
Results: The study group (vitamin C) presented a mortality of 13.04%, and mortality of 47.82%. The APACHE II showed no difference from the third day with vitamin C (p = 0.001). The total decrease in mortality was 7% lower risk of dying compared to 35.29% in the control group.
Conclusions: Vitamin C reduces mortality and morbidity in patients with severe sepsis and septic shock.


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