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2018, Number 1

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Gac Med Mex 2018; 154 (1)

Gabapentina a dosis de 300 vs. 450 mg como premedicación anestésica para hipertensión reactiva, ansiedad y analgesia

Rascón-Martínez DM, Guzmán-Sánchez JA, Corral-Urdapilleta NP, Arguelles-Uribe GD, Velázquez-Loeza J, Soto-Palma G, Carrillo-Torres O

Language: Spanish
References: 35
Page: 54-61
PDF size: 299.43 Kb.


ABSTRACT

Objective: Observe the behavior of gabapentin to reduce reactive hypertension secondary to anxiety and pain in patients undergoing ophthalmic surgery as well as opioid consumption between groups. Method: Clinical randomized double blind controlled trial that analyzed 125 patients divided into three groups: Group A, gabapentin 300 mg; Group B, gabapentin 450 mg; and Group C, amaranth dragees as a control 2 h before the surgical procedure. Chi-squared test was used in sociodemographic variables and one-way ANOVA for continuous numeric variables. It was considered as significant a p ‹ 0.05 for a study of two tails with a power of 80% beta. Results: Anxiety and analgesia intraoperative and postoperative had significant differences between groups. Lower consumption of opioid was found in the groups that used gabapentin. Conclusions: Gabapentin orally 300 or 450 mg h prior to surgery reduces pain, anxiety and postoperative opioid consumption in patients undergoing ophthalmic surgery.


REFERENCES

  1. Rosenman RH. Does anxiety or cardiovascular reactivity have a causal role in hypertension? Integr Physiol Behav Sci. 1991;26:296-304.

  2. Goldmann L, Ogg TW, Levey AB. Hypnosis and day case anaesthesia. A study to reduce pre-operative anxiety and intraoperative anaesthetic requirements. Anaesthesia. 1988;43:466-9.

  3. Maranets I, Kain ZN. Pre-operative anxiety and intra operative anesthetic requirements. Anesthesia and Analgesia.1999;89:1346-51.

  4. Caumo W, Schmidt AP, Schneider CN, et al. Risk factors for pre-operative anxiety in adults. Acta Anaesthesiologica Scandinavica. 2001;45:298-307.

  5. Londsdale M, Hutchison GL. Patients desire for information about anaesthesia: Scottish and Canadian attitudes. Anaesthesia. 1991;46: 410-2.

  6. Thomas T, Robinson C, Champion D, et al. Prediction and assessment of the severity of post-operative pain and of satisfaction with management. Pain. 1998;75:177-85.

  7. Al-Mujadi H, A-Refai AR, Katzarov MG, et al. Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Can J Anesth. 2006;53:268-73.

  8. Thomas V, Heath M, Rose D, et al. Psychological characteristics and the effectiveness of patient-controlled analgesia. Br J Anaesth. 1995;74: 271-6.

  9. Moix J. Emoción y cirugía. An Psicol. 1994;10:111-8.

  10. Izurieta R, Jeffrey TR. Sedation during mechanical ventilation: a systematic review. Crit Care Med. 2002;30:118-25.

  11. L’Abbé LA, Detsky AS, O’Rourke K. Meta-analysis in clinical research. Ann Intern Med. 1987;107:224-33.

  12. Wetsch WA, Lederer W, Kinz F, et al. Preoperative stress and anxiety in day-care patients and in patients undergoing fast-track surgery. Br J Anaesth. 2009;103:199-205.

  13. Busch JA, Radulovic LL, Bockbrader HN. Effect of Maalox TC on single- dose pharmacokinetics of gabapentin capsules in healthy subjects. Pharm Res. 1992;9:315.

  14. Pollack MH, Matthews J, Scott EL. Gabapentin as a potential treatment for anxiety disorders. Am J Psychiatry. 1998;155:992-3.

  15. Turan A, Karamanlioglu B, Memis D, et al. The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg. 2004;98:1370-3.

  16. Turan A, Memis D, Karamanlioglu B, et al. The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesth Analg. 2004;99:375-8.

  17. Gilron I, Biederman J, Jhamandas K, et al. Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw pressure and tail-flick tests. Anesthesiology. 2003;98:1288-92.

  18. Kong VK. Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth. 2007;99:775-86.

  19. Tirault M, Foucan M, Debaene B, et al. Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction. Acta Anaesth. 2010;61:203-9.

  20. Fassoulaki A, Triga A, Melemeni A, et al. Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg. 2005;101:1427-32.

  21. Rickels K, Pollack MH, Feltner DE, et al. Pregabalin for treatment of generalized anxiety disorder. A 4-week, multicenter, double-blind, placebo- controlled trial of pregabalin and alprazolam. Arch Gen Psychiatry. 2005;62:1022-30.

  22. Tipanna EM, Hamunen K, Kontinen VK, et al. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007;104:1545-56.

  23. Adam F, Ménigaux C, Sessler DI, et al. A single preoperative dose of gabapentin (800 milligrams) does not augment postoperative analgesia in patients given interscalene brachial plexus blocks for arthroscopic shoulder surgery. Anesth Analg. 2006;103:1278-82.

  24. Bonhaus DW, Loo C, Secchi R, et al. Effects of the GABAB receptor antagonist CGP 55845 on the anticonvulsant and anxiolytic actions of gabapentin. Pharmacologist. 2002;44:100.

  25. Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anesth. 2006;53:461-9.

  26. Montazeri K, Kashefi P, Honarmand A. Pre-emptive gabapentin significantly reduces postoperative pain and morphine demand following lower extremity orthopaedic surgery. Med J. 2007;48:748.

  27. Azeem E, Marey H. The effect of gabapentin premedication on pain and anxiety during cataract surgery under peribulbar block. Egyptian Journal of Anesthesia. 2012;28:43-7.

  28. Farzi F, Haddadi S, Ebrahimpour N, et al. A survey on the effect of oral gabapentin on hemodynamic changes during direct laryngoscopy and tracheal intubation and intraoperative bleeding in patients undergoing septorhinoplasty. Anesth Pain Med. 2015;5:29705.

  29. Susan A, Everson JW, Lynch GA, et al. Stress-induced blood pressure reactivity and incident stroke in middle-aged men. Stroke. 2001;32:1263-70.

  30. Doñate-Marín D, Litago-Cortés A, Monge-Sanz Y, et al. Aspectos de la información preoperatoria relacionada con la ansiedad del paciente programado para cirugía. Enfermeria Global. 2015;37:170-80.

  31. Ménigaux C, Adam F, Guignard B, et al. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg. 2005;100:1394-9.

  32. Chouinard G, Beauclair L, Belanger MC. Gabapentin: long-term antianxiety and hypnotic effects in psychiatric patients with comorbid anxiety- related disorders. Can J Psychiatry. 1998;43:305.

  33. Chang CY, Challa CK, Shah J, et al. Gabapentin in acute postoperative pain management. Biomed Res Int. 2014;2014:631756.

  34. Melemeni A, Staikou C, Fassoulaki A. Gabapentin for acute and chronic post-surgical pain. Signa Vitae 2. Pharmamed. 2007;1:42-51.

  35. Peng PW, Wijeysundera DN, Li CC. Use of gabapentin for perioperative pain control: a meta-analysis. Pain Res Manag. 2007;12:85-92.




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