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Academia Mexicana de Neurología, A.C.

2018, Number 1

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Rev Mex Neuroci 2018; 19 (1)

Crossroads kidney - brain in vascular cognitive impairment

Mimenza-Alvarado AJ, Aguilar-Navarro SG, Ramírez Sandoval JC, Hernández-Contreras FJ, Anaya-Escamilla A, Ávila-Funes JA

Language: Spanish
References: 56
Page: 68-79
PDF size: 298.92 Kb.


ABSTRACT

Individuals with chronic kidney disease (CKD), especially older adults, are at increased risk of developing cognitive impairment associated with renal disease, may present as minor neurocognitive disorder (NMS) or as a major neurocognitive disorder (dementia). Studies have shown that up to 87% of patients in the final stage of CKD have some degree of cognitive impairment. Currently, both conditions represent a major social and economic problem for the world’s public health systems. Our country is no exception, epidemiological studies have shown the existence of cognitive impairment in all stages of renal disease. The presence of this has a great impact on the quality of life of these patients.
Clinical and subclinical cerebrovascular disease are the main risk factor for cognitive impairment in patients with renal disease, although potential pathophysiological mechanisms such as direct neuronal damage by uremic toxins have also been studied. The aim of the present study is to describe the participation of clinical and subclinical cerebral vascular damage and to analyze the most important pathophysiological mechanisms in the brain-kidney interaction, to better understand the cognitive impairment in patients with CKD.


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