2018, Número 1
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Rev Mex Neuroci 2018; 19 (1)
Corea de sydenham: revisión práctica de la literatura actual
Vásquez-Builes S, Correa-Roldan MC, Rojas-Gallego IC, Tieck MP, Díaz-Silva GA
Idioma: Español
Referencias bibliográficas: 67
Paginas: 56-67
Archivo PDF: 289.14 Kb.
RESUMEN
Los trastornos del movimiento inmuno-mediados nos han
acompañado a lo largo de la historia. La corea de Sydenham, el más
frecuente de estos trastornos, fue descrito en el siglo XVII y aun es
reconocida como la causa más común de corea adquirida durante
la infancia. A pesar de su clara relación con la fiebre reumática, la
patogénesis de la corea de Sydenham no ha sido completamente
dilucidada. La similitud entre determinantes antigénicos de proteínas
del estreptococo beta hemolítico del grupo A y proteínas neuronales
ubicadas en los núcleos basales del huésped podrían llevar a una
reacción inmune cruzada y explicar las anormalidades funcionales y
parte de las manifestaciones clínicas, motoras y cognitivas, descritas
en este trastorno. Las manifestaciones clínicas de la corea de
Sydenham son diversas por lo cual el diagnóstico y el tratamiento a
menudo requieren enfoques multimodales.
En la presente revisión se realiza una descripción práctica y detallada
de la literatura actual sobre la corea de Sydenham enfatizando en
aspectos clínicos, fisiopatológicos y terapéuticos.
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