2018, Number 1
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Rev Mex Neuroci 2018; 19 (1)
Sydenham’s chorea: a practical review of current literature
Vásquez-Builes S, Correa-Roldan MC, Rojas-Gallego IC, Tieck MP, Díaz-Silva GA
Language: Spanish
References: 67
Page: 56-67
PDF size: 289.14 Kb.
ABSTRACT
The immune-mediated movement disorders have accompanied us
throughout history. Sydenham´s chorea is the most common cause
of chorea acquired during infancy. Despite its clear association with
rheumatic fever, the pathogenesis of Sydenham’s chorea has not
been fully elucidated. Autoimmune mechanisms are thought to play a
key role in the production of antineuronal antibodies. Cross-reaction
between Streptococcus pyogenes proteins and proteins expressed
in the striated body would be explained for molecular mimicry.
The clinical manifestations of Sydenham´s chorea are diverse. The
diagnosis and treatment of Sydenham´s chorea require a multimodal
approach.
The present work is a practical and detailed review of the literature
of Sydenham’s chorea, including the clinical, pathophysiological and
therapeutic aspects of the disease.
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