2018, Number 1
<< Back Next >>
An Med Asoc Med Hosp ABC 2018; 63 (1)
Neuronal party: pediatric status epilepticus
Oliva MHOM, Ochoa MX
Language: Spanish
References: 50
Page: 38-47
PDF size: 259.39 Kb.
ABSTRACT
Status epilepticus is the most common neurological emergency in children; it has high morbidity and mortality and requires an early and aggressive management. The International League Against Epilepsy defines the status epilepticus as a condition resulting from the failure of the mechanisms responsible for the termination of a crisis or the initiation of another, which lead to abnormally prolonged crisis. The minimum time criterion for defining status epilepticus was reduced from 30 to five minutes; it is defined as a continuous convulsive activity or rapid, recurrent seizures without recovery of consciousness for more than five minutes. This definition considers those crises that persist for more than five minutes, and establishes that they will probably last more than 30. «Refractory status epilepticus» is a seizure that continues despite treatment with benzodiazepines and antiepileptic drugs. «Super refractory status epilepticus» is the one that does not respond to anesthetic medication or relapses during its withdrawal. Status epilepticus can be clinically classified as convulsive, non-convulsive or refractory. Once the diagnosis is made, the treatment should start immediately, with the aims of finishing the event, preventing recurrences and handling precipitating causes and complications. The aim of this review is to provide and update the concepts, pathophysiology, etiology and antiepileptic treatment available for status epilepticus and to propose a rational management scheme.
REFERENCES
Cavanagh S, Liversedge T. Status epilepticus in children. Anaesthesia tutorial of the week 248. 2012. Disponible en: http://e-safe-anaesthesia.org/e_library/08/Status_Epilepticus_in_Children_TOTW_248_2012.pdf
Sánchez-Fernández I, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL et al. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017; 88 (4): 386-394.
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S et al. A definition and classification of status epilepticus —Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015; 56 (10): 1515-1523.
Chen JW, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006; 5 (3): 246-256.
Abend NS, Loddenkemper T. Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014; 16 (7): 301.
Vargas CP, Varela EX, Kleinsteuber SK, Cortés ZR, Avaria MA. Revisión del estado epiléptico convulsivo pediátrico y su manejo antiepiléptico. Rev Med Chile. 2016; 144: 83-93.
Singh SP, Agarwal S, Faulkner M. Refractory status epilepticus. Ann Indian Acad Neurol. 2014; 17 (Suppl 1): S32-S36.
Behera K, Rana S, Kanitkar M, Adhikari M. Status epilepticus in children. Med J Armed Forces India. 2005; 61 (2): 174-178.
Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011; 134 (Pt 10): 2802-2818.
Singhal A, Tripathi M. Refractory status epilepticus. Neurology Asia. 2013; 18 (Supplement 1): 67-71.
Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012; 17 (1): 3-23.
Conway SL, Horton ER. Emergent treatment of status epilepticus in children. US Pharm. 2015; 40 (5): HS25-HS31.
Wilmshurst J. Management of children with status epilepticus. JICNA. 2015; 15: 104.
Singh RK, Gaillard WD. Status epilepticus in children. Curr Neurol Neurosci Rep. 2009; 9 (2): 137-144.
Kinney M, Craig J. Grand rounds: an update on convulsive status epilepticus. Ulster Med J. 2015; 84 (2): 88-93.
Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J et al. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016; 16 (1): 48-61.
Lee J, Huh L, Korn P, Farrell K. Guideline for the management of convulsive status epilepticus in infants and children. BCMJ. 2011; 53 (6): 279-285.
Nair PP, Kalita J, Misra UK. Status epilepticus: why, what, and how. J Postgrad Med. 2011; 57 (3): 242-252.
Bassin S, Smith TL, Bleck TP. Clinical review: status epilepticus. Crit Care. 2002; 6 (2): 137-142.
Pellock JM. Status epilepticus in children: update and review. J Child Neurol. 1994; 9 Suppl 2: 27-35.
Riviello JJ Jr, Ashwal S, Hirtz D, Glauser T, Ballaban-Gil K, Kelley K et al. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2006; 67 (9): 1542-1550.
Office of Kids and Families. Infants and children: acute management of seizures. Health NSW Government; 2016. pp. 4-18.
Wasterlain CG, Fujikawa DG, Penix L, Sankar R. Pathophysiological mechanisms of brain damage from status epilepticus. Epilepsia. 1993; 34 Suppl 1: S37-S53.
Wasterlain CG, Baxter CF, Baldwin RA. GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus. Neurochem Res. 1993; 18 (4): 527-532.
Fazekas F, Kapeller P, Schmidt R, Stollberger R, Varosanec S, Offenbacher H et al. Magnetic resonance imaging and spectroscopy findings after focal status epilepticus. Epilepsia. 1995; 36 (9): 946-949.
Smith DM, McGinnis EL, Walleigh DJ, Abend NS. Management of status epilepticus in children. J Clin Med. 2016; 5 (4). pii: E47.
Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011; 10 (10): 922-930.
García S, Sauri SS, Meza E, Villagómez-Ortiz AJ. Estado epiléptico (status epilepticus): urgencia neurológica. Rev Asoc Mex Med Crit y Ter Int. 2013; 27 (1): 43-52.
Mata-Vicente JF. Estado epiléptico refractario en el entorno de la terapia intensiva. Rev Asoc Mex Med Crit y Ter Int. 2014; 28 (3): 175-186.
Walker M. Status epilepticus: an evidence based guide. BMJ. 2005; 331 (7518): 673-677.
Verrotti A, Ambrosi M, Pavone P, Striano P. Pediatric status epilepticus: improved management with new drug therapies? Expert Opin Pharmacother. 2017; 18 (8): 789-798.
Raspall-Chaure M, Chin RF, Neville BG, Scott RC. Outcome of paediatric convulsive status epilepticus: a systematic review. Lancet Neurol. 2006; 5 (9): 769-779.
Tunik MG, Young GM. Status epilepticus in children. The acute management. Pediatr Clin North Am. 1992; 39 (5): 1007-1030.
Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012; 366 (7): 591-600.
Prensky AL, Raff MC, Moore MJ, Schwab RS. Intravenous diazepam in the treatment of prolonged seizure activity. N Engl J Med. 1967; 276 (14): 779-784.
Wilkes R, Tasker RC. Intensive care treatment of uncontrolled status epilepticus in children: systematic literature search of midazolam and anesthetic therapies. Pediatr Crit Care Med. 2014; 15 (7): 632-639.
Alvarez V, Januel JM, Burnand B, Rossetti AO. Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia. 2011; 52 (7): 1292-1296.
Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998; 339 (12): 792-798.
Surges R, Volynski KE, Walker MC. Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther Adv Neurol Disord. 2008; 1 (1): 13-24.
Lewena S, Young S. When benzodiazepines fail: how effective is second line therapy for status epilepticus in children? Emerg Med Australas. 2006; 18 (1): 45-50.
Chin RF, Verhulst L, Neville BG, Peters MJ, Scott RC. Inappropriate emergency management of status epilepticus in children contributes to need for intensive care. J Neurol Neurosurg Psychiatry. 2004; 75 (11): 1584-1588.
Freilich ER, Schreiber JM, Zelleke T, Gaillard WD. Pediatric status epilepticus: identification and evaluation. Curr Opin Pediatr. 2014; 26 (6): 655-661.
Kim JS, Lee JH, Ryu HW, Lim BC, Hwang H, Chae JH et al. Effectiveness of intravenous levetiracetam as an adjunctive treatment in pediatric refractory status epilepticus. Pediatr Emerg Care. 2014; 30 (8): 525-528.
Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr. 2014; 26 (6): 668-674.
Tasker RC, Goodkin HP, Sánchez-Fernández I, Chapman KE, Abend NS, Arya R et al. Refractory status epilepticus in children: intention to treat with continuous infusions of midazolam and pentobarbital. Pediatr Crit Care Med. 2016; 17 (10): 968-975.
Nathan B, Smith T, Bleck T. The use of ketamine in refractory status epilepticus. Neurology. 2002; 58: A197.
Sheth RD, Gidal BE. Refractory status epilepticus: response to ketamine. Neurology. 1998; 51 (6): 1765-1766.
Keros S, Buraniqi E, Alex B, Antonetty A, Fialho H, Hafeez B et al. Increasing ketamine use for refractory status epilepticus in US pediatric hospitals. J Child Neurol. 2017; 32 (7): 638-646.
Sánchez-Fernández I, Abend NS, Agadi S, An S, Arya R, Brenton JN et al. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015; 84 (23): 2304-2311.
Riviello JJ Jr, Claassen J, LaRoche SM, Sperling MR, Alldredge B, Bleck TP et al. Treatment of status epilepticus: an international survey of experts. Neurocrit Care. 2013; 18 (2): 193-200.