2018, Number 1
<< Back Next >>
An Med Asoc Med Hosp ABC 2018; 63 (1)
Validation of the new definition of sepsis in the emergency department
Ochoa MX, Cano EAA, Tapia IEX, López CF, Pérez RBGR, Sánchez CA, Montiel FHM
Language: Spanish
References: 22
Page: 6-13
PDF size: 259.18 Kb.
ABSTRACT
Background: Currently sepsis is considered one of the main causes of multiple organ dysfunction and increase in the mortality of those patients who are diagnosed in the emergency department.
Objective: To determine the sensitivity and specificity of the definitions of sepsis and septic shock of the Third International Consensus of 2016 and of the Surviving Sepsis Campaign of 2012, as well as their prognostic validity for mortality in patients with these diagnoses in the emergency department.
Material and methods: Bicentric, prospective, descriptive, observational, longitudinal and prolective study. All patients older than 18 years who were admitted to the Emergency Department of the ABC Medical Center with the suspicion of sepsis or septic shock, with or without an identified focus, were evaluated from March 2016 to March 2017.
Results: One hundred patients were included, with an average entry score of rapid sequential organic failure assessment (qSOFA), sequential organic failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II of 1.4 (SD ± 0.9), 9.2 (SD ± 4.4) and 24.2 (SD ± 13.6) points, respectively. The overall mortality was 26.5%. A greater proportion of patients fulfilled criteria for septic shock using the definition of the Surviving to Sepsis Campaign of 2012, with 56 vs. 48% when using the Third International Consensus of 2016.
Conclusions: We observed that a greater proportion of patients fulfilled criteria for septic shock by the definition of the Surviving Sepsis Campaign of 2012, with 56 vs. 48%; for this reason, the septic patients were diagnosed earlier. However, the criteria of the Third International Consensus predicts earlier the severity of the illness as well as mortality.
REFERENCES
Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A et al. Assessment of clinical criteria for sepsis: for the Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016; 315 (8): 762-774.
Torio CM, Andrews RM. National inpatient hospital costs: the most expensive conditions by payer, 2011: Statistical Brief #160. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013.
Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013; 41 (5): 1167-1174.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013; 41 (2): 580-637.
Rhee C, Gohil S, Klompas M. Regulatory mandates for sepsis care —reasons for caution. N Engl J Med. 2014; 370 (18): 1673-1676.
Vincent JL, Marshall JC, Namendys-Silva SA, François B, Martin-Loeches I, Lipman J et al. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet Respir Med. 2014; 2 (5): 380-386.
Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016; 193 (3): 259-272.
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992; 20 (6): 864-874.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003; 31 (4): 1250-1256.
Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013; 369 (9): 840-851.
Vincent JL, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet. 2013; 381 (9868): 774-775.
Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS et al. Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016; 315 (8): 775-787.
Wiersinga WJ, Leopold SJ, Cranendonk DR, van der Poll T. Host innate immune responses to sepsis. Virulence. 2014; 5 (1): 36-44.
Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013; 13 (12): 862-874.
Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity. 2014; 40 (4): 463-475.
Singer M, De Santis V, Vitale D, Jeffcoate W. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet. 2004; 364 (9433): 545-548.
Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013; 93 (3): 1247-1288.
Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med. 2015; 191 (3): 309-315.
Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C et al. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013; 5 (195): 195ra95.
Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015; 372 (17): 1629-1638.
Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996; 22 (7): 707-710.
Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European Society of Intensive Care Medicine. Crit Care Med. 1998; 26 (11): 1793-1800.