Alert SJ, Chon RI, Ropero TR, Reno CJ, Verdecia CC, Valdés MJ, Pérez TM, García SD, Forteza SM, del Castillo BR

Language: Spanish
References: 0
Page: 310-318
PDF size: 141.53 Kb.

ABSTRACT

Introduction: Hodgkin's disease is one of the three most common malignant illnesses seen in children and adolescents in Cuba. The current treatment is based on the combination of chemotherapy and radiotherapy, with excellent results. Objective: to present the assessment of the application of radiation therapy after chemotherapy and to determine the most frequent histological types treated in our setting. Methods: non-randomized retrospective study of 54 patients aged 4 to 18 years, who were diagnosed with Hodgkin disease and radiated at the National Institute of Oncology and Radiobiology in Havana, from January 2008 to December 2014. These patients were followed-up until October 2016 and they had previously received polychemotherapy, as part of a planned treatment, according to several schemes and with different intensity during 4, 6 and 8 cycles, and later radiotherapy in their initially affected sites. Results: the patients were classified; 42 (77.8 %) belonged to the nodular sclerosis histological type, 8 (14.8 %) to mixed cellularity and 4 (7.4 %) to lymphocyte infiltration. Seventeen (31.5 %) patients classified as risk 1, 13 (24.1 %) as risk 2 and 24 (44.4 %) as risk 3. The accrued survival rate, which was estimated by the Kaplan-Meier method for all the patients, was 91.4 % at 8 years. Conclusions: survival rate was similar to that of other series, taking into account that 44.4 % of patients were high risk and the radiation therapy proved to be effective, since it was just applied in 3 initially irradiated patients.