2017, Number 6
<< Back Next >>
Med Int Mex 2017; 33 (6)
Legarreta- Holguín, Mauricio A Flores-Rosillo 746 Thromboprophylaxis in medical and surgical patients: results of a multicenter study in hospitals of Mexico City
Cabrera-Rayo A, Hernández-Díaz EJ, Guzmán-Rosales G, Laguna-Hernández G, Pliego-Reyes C, Zendejas-Villanueva JL, Pedraza-Méndez H, Rosas-Solís MI, Rivera-Guevara ML, Ortega-Román D, Lozano-Villalba FM, García-Méndez N, Hernández-Cid de León S, Mata-Ruiz B, Ramírez-Montelongo S, Avilés-Hernández R, Duque-Molina C
Language: Spanish
References: 18
Page: 746-753
PDF size: 586.00 Kb.
ABSTRACT
Background: Venous thromboembolic disease (VTE) is a complication
that may occur during or after hospitalization. There are few antecedents
in our country that evaluate the medical behavior in this subject.
Objective: To know the prescription related to type, duration and possible
causes for omission of thromboprophylaxis in hospitalized patients.
Material and Method: A descriptive, transversal and nonprobabilistic
study was done, in which from September to November
2016 physicians of Internal Medicine, General Surgery, Intensive Care
and Urgency were evaluated through a data collection by questionnaire
and presentation of results through descriptive statistics. We also
evaluated duration of prescription and dose administered.
Results: A total of 556 seconded physicians, 14 service heads, and
234 residents (804 in total) were surveyed in seven hospitals in Mexico
City belonging to the health system. Thirty percent reported that their
hospital has a thromboprophylaxis program; 97.7% consider it safe and
1.2% risky; 96% responded that they prescribe thromboprophylaxis in
their patients; 592 (73.6%) used some clinical prediction scale for VTE;
71% recommended low molecular weight heparin for thrombo prophylaxis
and 0.74% administered new generation oral anticoagulants.
Conclusions: Venous thromboembolic disease is potentially preventable;
however, prescription shows opportunities for improvement
in aspects of pharmacology.
REFERENCES
Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol 2007;44(2):62-69.
Anderson FA Jr, Zayaruzny M, Heit JA, Fidan D, Cohen AT. Estimated annual numbers of US acute-care hospital patients at risk for venous thromboembolism. Am J Hematol 2007 Sep;82(9):777-82.
Cabrera-Rayo A, Laguna-Hernández G, Reyes-López D, Torres-Narváez P y col. Riesgo de enfermedad tromboembólica venosa en pacientes con enfermedad aguda internados en urgencias. Med Int Mex 2010;26(1):31-35.
National Institute for Health and Clinical Excellence. Venous thromboembolism - reducing the risk (CG92). 2010. http:// guidance.nice.org.uk/CG92.
Kesieme E, Kesieme C, Jebbin N, et al. Deep vein thrombosis: a clinical review. J Blood Med 2011;2:59-69.
Maynard GA, Morris TA, Jenkins IH, Stone S, Lee J, Renvall M et al. Optimizing Prevention of Hospital-acquired Venous Thromboembolism (VTE): Prospective Validation of a VTE Risk Assessment Model. J Hosp Med 2010;5:10-18.
Pai M, Lloyd NS, Cheng J, Thabane L, Spencer FA, Cook DJ et al. Strategies to enhance venous thromboprophylaxis in hospitalized medical patients (SENTRY): a pilot cluster randomized trial. Implementation Science 2013;8.
Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson FA Jr; ENDORSE Investigators. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 2008 Jun 7;371(9628):1914.
Goldhaber SZ, Tapson VF. A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 2004;93:259-62.
Martínez-Zubieta R. Tromboembolismo venoso y profilaxis en enfermedades agudas hospitalarias. Resultados en México de un estudio transversal multicéntrico (ENDORSE II). Cir 2010;78:333-341.
Sykes PK, Walsh K, Darcey CM, Hawkins HL, McKenzie DS, Prasad R, Thomas A. Prevention of venous thromboembolism amongst patients in an acute tertiary referral teaching public hospital: a best practice implementation project. Int J Evid Based Healthc 2016 Jun;14(2):64-73.
Deheinzelin D, Braga AL, Martins LC, Martins MA, et al. Incorrect use of thromboprophylaxis for venous thromboembolism in medical and surgical patients: results of a multicentric, observational and cross-sectional study in Brazil. J Thromb Haemost 2006 Jun;4(6):1266-70.
Dentali F, Douketis JD, Gianni M, Lim W, Crowther MA. Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Ann Intern Med 2007 Feb 20;146(4):278-88.
Själander A, Jansson JH, Bergqvist D, Eriksson H, Carlberg B, Svensson P. Efficacy and safety of anticoagulant prophylaxis to prevent venous thromboembolism in acutely ill medical inpatients: a meta-analysis. J Intern Med 2008 Jan;263(1):52-60.
Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg 1999;86(8):992-1004.
Kakkos SK, Caprini J A, Geroulakos G, Nicolaides A N, Stansby G P, Reddy D J. Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients. Cochrane Database Syst Rev 2008;4):CD005258.
Saleh Rachidi, Ehab Saad Aldin, Charles Greenberg, Barton Sachs, Michael Streiff, and Amer M Zeidan. The use of novel oral anticoagulants for thromboprophylaxis after elective major orthopedic surgery Expert Rev Hematol 2013 Dec;6(6):677-695. doi: 10.1586/17474086.2013.853430.
Amin AN, Lin J, Ryan A. Need to improve thromboprophylaxis across the continuum of care for surgical patients. Adv Ther 2010 Feb;27(2):81-93.