Staines-Orozco H, González-Aguirre A, Soto-Germes S, Staines-Alarcon R

Language: Spanish
References: 18
Page: 90-98
PDF size: 625.31 Kb.

ABSTRACT

The disease known as Persistent Hyperinsulinemic Hypoglycemia of Infancy, known in the past as Nesidioblastosis, is a genetic disease that is generated by an inappropriate secretion of insulin, the patient presents with hypoglycemia and convulsive crisis near after born. Molecular studies have shown the incapacity of the K ATP channel to control the polarization of the membrane of pancreatic b cells when the former subunits have defects; mutations in 11p15.1 are related whit structural defects in the K ATP channel generating a continuous depolarization and an uncontrolled insulin secretion. We present a case of a female patient wiht 37 weeks of gestational age, birth weight of 4,300 gms, APGAR 7-9 that is admitted to the Intensive Care Unit of the Hospital General de Ciudad Juárez presenting generalized convulsions due to the persistent hypoglycemia during the first hours of life.

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