medigraphic.com
ISSN 2992-8036 (Electronic)
ISSN 2306-4102 (Print)
Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología

2017, Number 4

<< Back Next >>

Acta Ortop Mex 2017; 31 (4)

Lumbar fusion with collagen type I and polyvinylpyrrolidone in combination with autograft. An experimental study in New Zealand rabbits

Reyes-Sánchez A, Reyes-Tarrago F, García-Ramos C, Zárate-Kalfópulos B, Estrada-Villaseñor E, Alpizar-Aguirre A

Language: English
References: 44
Page: 165-170
PDF size: 169.71 Kb.


ABSTRACT

Introduction: Multiple strategies have been developed looking for upgrading the consolidation rate of spine arthrodesis with autolog bone graft, but no evidence exists that adhesion with Collagen type 1 and polyvinylpyrrolidone (FibroquelMR) have application on this field. Objective: Determine if collagen type 1 + Polyvinylpyrrolidone are effective as bone enhancer in posterolateral arthrodesis on rabbits. Method: Posterolateral arthrodesis in 15 New Zealand rabbits on level L5-L6 using autolog bone graft in left side (control group) and autolog bone graft + 1 ml FibroquelMR (study group) in right side of arthrodesis. Euthanasia and block resection of lumbar segment eight weeks post surgery. Radiographic analysis, manual exploration and light microscopy of fussed segments. Results: Radiographic consolidation was observed in 80% in control group and 95% in study group, interleaved trabecular pattern with bone continuity and normal characteristics in 12 left sides and 14 right sides. Conclusion: Collagen type 1 and polyvinylpyrrolidone use is likely to have positive effect in bone consolidation process, therefore it can be recommended to use it as a bone enhancer.


REFERENCES

  1. Vacarro AR, Patel TC, Fischgrund J, Anderson DG, Truumees E, Herkowitz HN, et al: A pilot study evaluating the safety and efficacy of OP-1 putty (shBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine. 2004; 29: 1885-92.

  2. Khan SN, Hidaka C, Sandhu HS, Girardi FP, Cammisa FP, Diwan AD: Gene therapy for spine fusion. Orthop Clin North Am. 2000; 31: 473-84.

  3. Gazdag AR, Lane JM, Glaser D, Forster RA: Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Ortho Surg. 1995; 3: 1-8.

  4. Whang PG, Wang JC: Bone graft substitutes for spinal fusion. Spine J. 2003; 3: 155-65.

  5. Stevenson S. Biology of bone grafts. Orthop Clin North Am. 1999; 30: 543-52.

  6. Greenwald AS, Boden SD, Goldberg VM, Khan Y, Laurencin CT, Rosier RN, et al. Bone graft substitutes: facts, fictions and applications. J Bone Joint Surg Am. 2001; 83: S98-103.

  7. Gazdag A, Lane J, Glaser D, Forster R. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Ortho Surg. 1995; 3: 1-8.

  8. Khan SN, Cammisa Jr H, Sandhu S, Diwan AD, Girardi FP, Lane JM: The biology of bone grafting. J Am Acad Orthop Surg. 2005; 13: 77-86.

  9. Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine. 2002; 27: S26-31.

  10. Bucholz RW, Carlton A, Holmes R: Interporous hydroxyapatite as bone graft substitute in tibial plateau fractures. Clin Orthop Relat Res. 1989; 240: 53-62.

  11. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res. 1981; 157: 259-78.

  12. Finkeimer CG: Bone-grafting and bone substitutes. J Bone Joint Surg Am. 2002; 84: 454-64.

  13. Cho DY, Lee WY, Sheu PC, Chen CC. Cage containing a biphasic calcium phosphate ceramic (Triosite) for the treatment of cervical spondylosis. Surg Neurol. 2005; 63: 497-503.

  14. Urist MR: Bone formation by autoinduction. Science. 1965; 150: 893-899.

  15. Ludwig SC, Boden SD: Osteoinductive bone graft substitutes for spinal fusion. Orthop Clin North Am. 1999; 30: 635-45.

  16. Chapman MW, Bucholz R, Cornell C: Treatment of acute fractures with collagen-calcium phosphate graft material. A randomized clinical trial. J Bone Joint Surg Am. 1997; 79: 495-502.

  17. Sandhu HS, Grewal HS, Parvataneni H. Bone grafting for spinal fusion. Orthop Clin North Am. 1999; 30: 685-98.

  18. Sassard WR, Eidman DK, Gray PM: Analysis of spine fusion utilizing demineralized bone matrix. Orthop Trans. 1994; 18: 886-7.

  19. Pietrazak WS, Perns SV, Keyes J, Woodell-May J, McDonald NM. Demineralized bone matriz graft: a scientific and clinical case study. J Foot Ankle Surg. 2005; 44: 345-53.

  20. Nade S, Armstrong L, McCartney E, Baggaley B: Osteogenesis after bone marrow transplantation: the ability of ceramic materials to sustain osteogenesis form transplanted bone marrow cells: preliminary studies. Clin Orthop Relat Res. 1983; 181: 255-63.

  21. Boden S: Bone Graft and Fusion-Enhancing substances: Practical Applications of Gene Therapy. In: Vaccaro Principles and Practice of Spine Surgery. Philadelphia: Mosby 2003, 127-39.

  22. Paley D, Young MC, Wiley AM, Fornasieer VL, Jackson RW: Percutaneous bone marrow grafting of fractures and bone defects:an experimental study in rabbits. Clin Orthop Relat Res. 1986; 208: 300-11.

  23. Conolly J, Guse R, Lippiello L, Dehne R: Development o fan osteogenic bone marrow preparation. J Bone Joint Surg Am. 1989; 71: 684-91.

  24. Muschler GF, Boehm C, Easley KA: Aspiration to obtain osteoblast progenitor cells from bone marrow: the influence of aspiration volume. J Bone Joint Surg Am. 1997; 79: 1699-709.

  25. Muschler GF, Nitto H, Boehrm C, Easley KA: Age and gender related changes to cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J Orthop Res. 2001; 19: 117-25.

  26. Inoue K. Ohgushi H, Yoshikawa T, Okumura M, Sempuku T, Tamai S, et al: The effects of aging on bone formation in porous hidroxyapatite: biochemical and histologic analysis. J Bone Miner Res. 1997; 12: 989-94.

  27. Tiedemann JJ, Garvin KL, Kile TA, Connolly JF: The role of a composite demineralized bone matrix and bone marrow in the treatment of osseus defects. Orthopaedics. 1995; 18: 1153-8.

  28. Whang PG, Wang JC: Bone graft substitutes for spinal fusion. Spine J. 2003; 3: 155-65.

  29. Haynesworth S, Kadiyala S, Bruder S: 4:48 Platelet rich plasma stimulates stem cell chemotaxis, proliferation and potentiates osteogenic differentiation. Spine J. 2002; 2: 68S.

  30. Schlegel KA, Donath K, Rupprecht S, Falk S, Zimmermann R, Felszeghy E, et al: De novo bone formation using bovine collagen and platelet-rich plasma. Biomaterials. 2004; 25: 5387-93.

  31. Arpornmaeklong P, Kochel M, Depprich R, Kübler NR, Würzler KK: Influence of platelet rich plasma PRP on osteogenic differentiation of rat bone marrow stromal cells an in vitro study. Int J Maxillofac Surg. 2004; 33: 60-70.

  32. Hutmacher DW, Garcia AJ: Scaffold-based bone engineering by using genetically modified cells. Gene. 2005; 347: 1-10.

  33. Doblaré M, García JM, Gómez MJ: Modelling bone tissue fracture and healing. Engineering Fract Mec. 2004; 71: 1809-40.

  34. Mayer U, Joos U, Wiesmann PH: Biological and biophysical principles in extracorporal bone tissue engineering: Part I. Int J Oral Maxillofac Surg. 2004; 33: 325-32.

  35. Sun JS, Wu SYA, Lin FH: The role of muscle-derived stem cells in bone tissue engineering. Biomaterials. 2005; 26: 3953-60.

  36. Orban J, Marra K, Hollinger J: Composition options for tissue-engineered bone. Tissue Eng. 2002; 8: 529-39.

  37. Caldelas-Cuéllar E, Zarur-Mina N. Rodilla del saltador. Tratamiento quirúrgico artroscópico combinado con rastrillaje y colágeno povidona en deportistas de alto rendimiento. Acta Ortop Mex. 2007; 21:234-8.

  38. Padilla L, Krötzsch E, Schalch P, Figueroa S, Miranda A, Rojas E, et al. Administration of bone marrow cells into surgically induced fibrocollagenous tunnels induces angiogenesis in ischemic rat hind limb model. Microsurgery. 2003; 23: 568-74.

  39. Furuzawa-Carballeda J, Rojas E, Valverde M, Castillo I, Diaz de León L, Krötzsch E. Cellular and Humoral responses to collagen-polyvinylpyrrolidone administred during short and long periods in humans. Can J Physiol Pharmacol. 2003; 81: 1029-35.

  40. Furuzawa CJ, Alconcer VJ, Díaz LL, Collagen PV: Decreases collagen turnover in synovial tissue cultures from rehumatoid arthritis patients. Ann N Y Acad Sci. 1998; 857: 232-6.

  41. Chimal-Monroy J, Bravo-Ruiz T, Krötzsch-Gómez FE, Díaz de León L. Implates de FibroquelMR aceleran la formación de hueso nuevo en defectos óseos inducidos experimentalmente en cráneos de rata: un estudio histológico. Rev Biomed. 1997; 8: 81-8.

  42. Boden SD, Schimandle JH, Hutton WC. An experimental lumbar intertransverse process spinal fusion model. Spine. 1995; 20(4): 412-20.

  43. Kaiser MG, Groff MW, Watters WC, Ghogawala Z, Mummaneni PV, Dailey AT, et al: Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: Bone graft extenders and substitutes as an adjunct for lumbar fusion. J Neurosurg Spine. 2014; 21: 106-32.

  44. Park JJ, Hershman SH, Kim YH. Updates in the use of bone grafts in the lumbar. Bull Hosp Jt Dis. 2013; 71 (1): 39-48.




2020     |     www.medigraphic.com