medigraphic.com

2014, Number 2

<< Back Next >>

Rev Educ Bioquimica 2014; 33 (2)

Poliaminas: pequeños gigantes de la regulación metabólica

Guasco HC, Chávez SJL, Ferriz MRA, de la Torre CK, Elton PE, García GT

Language: Spanish
References: 35
Page: 51-57
PDF size: 427.47 Kb.


ABSTRACT

Polyamines are nitrogenated aliphatic molecules of low molecular weight with regular-distributed amino groups along its structure. Among their main functions are packaging of nucleic acids, modulation of membrane receptors and ion channels, regulation of gene expression and cell signaling. They can induce apoptosis, participate in cell cycle, modulate the immune system and the redox balance of the body. They are considered anti-inflammatory molecules and are associated with longevity. However, poliamines are involved in cancer and neurodegenerative diseases, then they are potential targets in pharmacology.


REFERENCES

  1. Bouchereau A, Aziz A, Larher F, Martin-Tanguy J (1999) Polyamines and environmental challenges: recent development. Plant Sci 140:103-125

  2. Fernández M , Alvarez MA (2008) Las Aminas Biógenas en los alimentos. Agrocsic. 2-8. Disponible en: http://digital.csic.es/ bitstream/10261/5771/1/IPLA_AGROCSIC_2. pdf

  3. Minois N, Carmona-Gutierrez D, Madeo F (2011) Polyamines in aging and disease. Aging 3:1-17

  4. Greene JM, Feugang JM, Pfeiffer KE, Stokes JV, Bowers SD, Ryan PL (2013) L-arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells. Rep Biol Endocrinol 11:15 pp

  5. Wang S-Y, Lee Y-L, Lai Y-H, Chen JJW, Wu W-LYuann JMP,Su W-L,Chuang S-M,Hou M-H (2012) Spermine attenuates the action of the DNA intercalator actinomycin D, on DNA binding and the inhibition of trasncription and DNA Replication. PLoS ONE 7: e47101.

  6. Bjelakovic L, Kocic G, Bjelakovic B, Najman S, Stojanovic D, Jonovin M, Pop-Trajkovic Z (2012) Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation. Iran J Pediatr. 22: 218–222.

  7. Ruiz-Cano D, Pérez-Llamasa F, Zamora S (2012) Polyamines, implications for infant health. Arch Argent Pediatr. 110(3):244-250.

  8. Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA Jr, Wilson KT (2004) Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J Biol Chem 279:40161-40173

  9. Aouida M, Leduc A, Poulin R, Ramotar D (2005) AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae. J. Biol. Chem. 280:24267-24276.

  10. Murakami Y, Matsufuji S, Hayashi S, Tanahashi N, Tanaka K (2000) Degradation of Ornithine Decarboxylase by the 26S Proteasome. Biochem Biophys Res Comm. 267:1-6

  11. Ouameur AA, Tajmir-Riahi HA (2004) Structural Analysis of DNA Interactions with Biogenic Polyamines and Cobalt(III) hexamine Studied by Fourier Transform Infrared and Capillary Electrophoresis. J Biol Chem. 279:42041- 42054.

  12. Bhattacharya S, Ray RM, Johnson LR (2009) Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal 21:509–522

  13. Landau G, Ran A, Bercovich Z, Feldmesser E, Horn-Saban S, Korkotian E, Jacob-Hirsh J, Rechavi G, Ron D, Kahana C (2012) Expression Profiling and Biochemical Analysis Suggest Stress Response as a Potential Mechanism Inhibiting Proliferation of Polyamine-depleted Cells. J Biol Chem 287:35825-35837.

  14. Brooks Wesley H (2012) Autoimmune Diseases and Polyamines. Clin Rev Allergy Immunol. 42:58-70

  15. Zhang M, Wang H, Tracey KJ (2000) Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit Care Med 28:N60-N66

  16. Keledjian KM, Marasa BS, Wang JY, Rao JN (2012) Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion. Int J Clin Exp Med 5:221- 228.

  17. Choi YH, Park HY (2012) Anti-inflammatory effects of spermidine in lipopolysaccharidestimulated BV2 microglial cells. J Biomed Sci 19:31

  18. Bachrach U, Wang Y-C, Tabib A (2001) Polyamines: New cues in cellular signal transduction. Physiology 16:106-109

  19. Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA (1998) The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci USA. 95:11140-11145.

  20. Kwak MK, Kensler TW, Casero RA Jr (2003) Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem Biophys Res Commun. 305(3):662-70.

  21. Cerrada-Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvönen MT, Keinänen TA, Jänne J, Alhonen L (2011) Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults. Transgenic Res. 20:387- 396.

  22. Nishimura K, Shiina R, Kashiwagi K, Iagarashi K (2006) Decrease in polyamines with aging and their ingestion from food and drink. J Biochem. 139: 81-90.

  23. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11:1305-14

  24. Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sigrist SJ, Kroemer G, Madeo F (2012) Spermidine promotes stress resistance in Drosophila melanogaster through autophagydependent and independent pathways. Cell Death Dis. 3:e401

  25. Morselli E, Galluzzi L, Kepp O, Criollo A, Chiara MM, Tavernarakis N, Madeo F, Kroemer G (2009) Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging. 1(12): 961-970

  26. Bachrach U (2004) Polyamines and Cancer: Minireview article. Amino Acids 26:307-309.

  27. Loria D, Sacerdote de Lustig E (1980) Poliaminas y cáncer. Medicina (Buenos Aires) 40:607-612

  28. Medina MA, Quesada AR, Nuñez de Castro I, Sanchez-Jimenez F (1999) Histamine, Polyamines, and Cancer. Biochem Pharmacol. 57:1341–1344.

  29. Pegg AE (2008) Spermidine/spermine-N1- acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab 294: E995– E1010

  30. Vargas AJ, Wertheim BC, Gerner EW, Thomson CA, Rock CL, Thompson PA (2012) Dietary polyamine intake and risk of colorectal adenomatous polyps. Am J Clin Nutr. 96:133- 141.

  31. Meyskens FL Jr, Gerner EW (1999) Review Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res. 5(5):945-51.

  32. Atiya Ali M, Strandvik B, Sabel KG, Palme Kilander C, Strömberg R, Yngve A (2013) Polyamine levels in breast milk are associated with mothers’ dietary intake and are higher in preterm than full-term human milk and formulas. J Hum Nutr Diet. doi: 10.1111/ jhn.12156

  33. Galgano F, Caruso M, Condelli N, Favati F (2012) Agmatine in Fermented Foods. Front Microbiol. 3: 1-7.

  34. Thanh Binh PN, Soda K, Kawakami M (2011) Mediterranean diet and polyamine intake: possible contribution of increased polyamine intake to inhibition of age-associated disease. Nutr Diet Suppl. (3):1-7.

  35. Papavergou EJ, Savvaidis IN, Ambrosiadis IA (2012) Levels of biogenic amines in retail market fermented meat products. Food Chem. 2012 135:2750-2755.




2020     |     www.medigraphic.com