2017, Number 2
<< Back Next >>
Rev Hosp Jua Mex 2017; 84 (2)
Reactivation of tuberculosis in oncological patients. Case report
Alonso-Bello CD, Cabrera-Galeana PA, Lara-Medina F, Conde-Mercado JM
Language: Spanish
References: 17
Page: 103-108
PDF size: 259.02 Kb.
ABSTRACT
Introduction: Cancer and tuberculosis (TB) are a global public health problem, their association is rare. In the natural history of TB,
Mycobacterium tuberculosis (MT) infection can heal, remain active and latent (TBL), cancer may be an unrecognized cause of TB reactivation, its knowledge is of great importance to suspect and diagnose TBL, and consider prophylaxis with isoniazid to prevent its reactivation. We present the case to review current concepts and the management of TBL in association with cancer.
Case report: A 62-year-old woman with type 2 diabetes mellitus and stage IV clinical breast cancer, on the second cycle of palliative chemotherapy, presented to urgency with hematuria and respiratory symptoms, diagnosed as disseminated tuberculosis (genitourinary, pulmonary and gastric).
Conclusions: The suspicion of TBL is of great importance to prevent a reactivation in the cancer patient.
REFERENCES
Seo GH, Kim MJ, Seo S, Hwang B, Lee E, Yun Y, et al. Cancer-specific incidence rates of tuberculosis: A 5-year nationwide population-based study in a country with an intermediate tuberculosis burden. Medicine (Baltimore) 2016; 95(38): e4919.
Fogel N. Tuberculosis: a disease without boundaries. Tuberculosis (Edinb) 2015; 95(5): 527-31.
World Health Organization. Gobal tuberculosis report 2016. [Consultado abril de 2017] URL Available in: http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf?ua=1.
Sauzullo I, Vullo V, Mastroianni CM. Detecting latent tuberculosis in compromised patients. Curr Opin Infect Dis 2015; 28(3): 275-82.
Simonsen DF, Farkas DK, Horsburgh CR, Thomsen RW, Sørensen HT. Increased risk of active tuberculosis after cancer diagnosis. J Infect 2017; 74(6): 590-8.
Vento S, Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol 2011; 12(6): 520-2.
Wu CY, Hu HY, Pu CY, Huang N, Shen HC, Li CP, et al. Aerodigestive tract, lung and haematological cancers are risk factors for tuberculosis: an 8-year population-based study. Int J Tuberc Lung Dis 2011; 15(1): 125-30.
Salgame P, Geadas C, Collins L, Jones-López E, Ellner JJ. Latent tuberculosis infection--Revisiting and revising concepts. Tuberculosis (Edinb) 2015; 95(4): 373-84.
Gupta A, Kaul A, Tsolaki AG, Kishore U, Bhakta S. Mycobacterium tuberculosis: immune evasion, latency and reactivation. Immunobiology 2012; 217(3): 363-74.
Mack U, Migliori G, Sester M, et al. LTBI: latent tuberculosis infection or lasting immune responses to M. Tubercolosis? A TBNET consensus statement. Eur Respir J. 2009; 33(5): 956-73.
Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. J Immunol 2010; 185(1): 15-22.
Kamboj M, Sepkowitz KA. The risk of tuberculosis in patients with cancer. Clin Infect Dis 2006; 42(11): 1592-5.
Jacobs RE, Gu P, Chachoua A. Reactivation of pulmonary tuberculosis during cancer treatment. Int J Mycobacteriol 2015; 4(4): 337-40.
Kim DK, Lee SW, Yoo CG, Kim YW, Han SK, Shim YS, et al. Clinical characteristics and treatment responses of tuberculosis in patients with malignancy receiving anticancer chemotherapy. Chest 2005; 128(4): 2218-22.
De La Rosa GR, Jacobson KL, Rolston KV, Raad II, Kontoyiannis DP, Safdar A. Mycobacterium tuberculosis at a comprehensive cancer centre: active disease in patients with underlying malignancy during 1990-2000. Clin Microbiol Infect 2004; 10(8): 749-52.
Huang SF, Li CP, Feng JY, Chao Y, Su WJ. Increased risk of tuberculosis after gastrectomy and chemotherapy in gastric cancer: a 7-year cohort study. Gastric Cancer 2011; 14(3): 257-65.
Ito K, Fujimori M, Shingu K, Hama Y, Kanai T, et al. Pulmonary tuberculosis in a patient receiving intensive chemotherapy for metastatic breast cancer. Breast J 2005; 11(1): 87-8.