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2002, Number 2

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Gac Med Mex 2002; 138 (2)

Usefulness of Radioimmunoscintigraphy Images with 111In.CYT-103 in the Diagnosis of Recurrence of Colon and Rectal Cancer.

García-Fernández R, Luna-Pérez P, Hernández-Hernández DM, Iwasaki-Otake L, Pichardo-Romero P, Rodríguez-Ramirez S

Language: Spanish
References: 30
Page: 139-144
PDF size: 116.17 Kb.


ABSTRACT

Objective: To determine the effectiveness of radioimmu-noscintigraphy (RIC) with 111In-CYT-103 in detecting the extension of malignant disease in patients surgically treated for colorectal adenocarcinoma under suspicion of recurrence in comparison to CT scan (computed tomography) and exploratory laparotomy. Design: Prospective and observational study. Material and Methods: A total of 26 patients under suspicion of recurrence, with a total of 31 lesions. All the patients had performed the following studies with GT, RIC with 111In-CYT-103, exploratory laparotomy and histopathology. Results: A sensitivity of 96.8%, and specificity of 77.8%, and accuracy of 92% were found for the RIC. CT scan had a sensitivity, specificity and accuracy of 71.5%, 88.8%, and75.7%, respectively in extrahepatic lesions. When both methods are combined, results shows an increment in sensitivity. Hepatic lesions were present in 50% of the patients; a sensitivity of 85%, a specificity of 92%, and accuracy of 89% for RIC and sensitivity, specificity and accuracy of 92% for the CT. Conclusion: the results of clinical studies with 111In-CYT-103 in detecting the occurrence of colorectal carcinoma provided additional information, making this method a valuable complementary test that contributes to patient management.


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