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ISSN 1561-3062 (Electronic)

2016, Number 4

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Revista Cubana de Obstetricia y Ginecología 2016; 42 (4)

Fetal ductus arteriosus constriction in the final third of pregnancy due to paracetamol comsumption

Dieste PP, Arrieta BS, Elizalde Martínez-Peñuela CR, García FJF, Hernández HJ

Language: Spanish
References: 14
Page: 493-501
PDF size: 398.29 Kb.


ABSTRACT

Ductus arteriosus is a derivation that connects the pulmonary artery with the aortic arch and allows the discharge from the right ventricle without passing the high resistance of lungs. Permeability of the ductus arteriosus is kept during gestation because of the production of prostaglandins, particularly PGE2, which circulates locally, and the low fetal oxygen saturation. Here is a pregnant woman who, since her 20th week of gestation was diagnosed as a renal colic case. She required several admissions to hospital and placement of double J stent in the urology service and she was treated with intravenous and oral paracetamol. Obstetric ultrasound scans throughout gestation were normal until week 32, when she was admitted to hospital again for suspected renal colic and treated again with paracetamol. At that moment, findings compatible with early ductus arteriosus constriction were observed in ultrasound. It was then decided to stop the paracetamol treatment, the changes declined in the following 48 hours and they almost disappeared completely after one week after the medication withdrawal. It was finally a term pregnancy and the postnatal echocardiogram of the newborn was normal. Restricting non-opioid analgesics in the third pregnancy trimester and the follow up of the ductus arteriosus with Doppler technique when required.


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