medigraphic.com

2016, Number S3

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2016; 54 (S3)

Relationship between the level of maternal glycated hemoglobin and fetal hypertrophic cardiomyopathy

Sánchez-Martínez KL, Oseguera-Torres LF, Avalos-Nuño J

Language: Spanish
References: 39
Page: 260-269
PDF size: 318.35 Kb.


ABSTRACT

Background: Diabetes mellitus is a metabolic disorder commonly associated with pregnancy. It is shown that as the management of diabetes during pregnancy is optimized, decreases the frequency and severity of fetal and neonatal complications. The aim of this paper is to identify the relation between the level of maternal glycated hemoglobin and fetal hypertrophic cardiomyopathy.
Methods: An analitytic cross-sectional study was conducted. It included patients with single pregnancy of 28-37 weeks diagnosed with gestational or preconception diabetes mellitus. A fetal echocardiogram were performed, likewise measuring of glycated hemoglobin.
Results: 104 diabetic pregnant patients were included in the study, 83 patients in the group with normal glycated hemoglobin and 21 in the group with altered glycated hemoglobin. Of the 104 patients, 12 had fetal hypertrophic cardiomyopathy; 5 of the group with normal glycated hemoglobin and 7 with altered glycated hemoglobin. There is a clear association previously reported between the level maternal metabolic control and the presence of fetal and neonatal complications.
Conclusions: A positive correlation between the values of high maternal glycated hemoglobin and increased thickness of the fetal ventricular septum was observed. Fetal echocardiographic assessment is recommended for all pregnant women with gestational and pre-pregnancy diabetes mellitus in order to early detection of fetal hypertrophic cardiomyopathy


REFERENCES

  1. Vargas R, Repke JT, Ural SH. Type 1 diabetes mellitus and pregnancy. Rev Obstet Gynecol. 2010;3(3): 92-100.

  2. Pauliks LB. The effect of pregestational diabetes on fetal heart function. Expert Rev Cardiovasc Ther. 2015;13(1):67-74.

  3. Nold JL, Georgieff MK. Infants of diabetic mothers. Pediatr Clin N Am. 2004;51(3):619-637.

  4. Hernández-Del Rio JE, Magaña-Cárdenas MT, Hernández- Flores MS. Miocardiopatía hipertrófica en el hijo de madre con diabetes. Rev Med MD. 2013;4 (3):152-157.

  5. Lawrence JM, Contreras R, Chen W, Sacks DA. Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999- 2005. Diabetes Care. 2008;31(5):899-904.

  6. Landon MB, Nicholson WK. ACOG Practice Bulletin Number 137. Gestational Diabetes Mellitus. Obstet Gynecol. 2013;122(2):406-16. 7 American Diabetes Association. Standards of Medical Care in Diabetes 2015. Diabetes Care. 2015;38 (Suppl. 1):S8-S16.

  7. Gabbe SG. ACOG Practice Bulletin Number 60 Pregestational Diabetes Mellitus. Obstet Gynecol. 2005;105(3):675-85.

  8. Contreras-Zuñiga E, Guillermo-Arango L, Zuluaga- Martínez SX, Ocampo V. Diabetes y embarazo. Revista Colombiana de Obstetricia y Ginecología. 2008;59(1):38-45.

  9. Sardesai MG, Gray AA, McGrath MMJ, Ford SE. Fatal Hypertrophic Cardiomyopathy in the fetus of woman with Diabetes. Obstet Gynecol. 2001;98(5): 925-927.

  10. García HJ, Rodas-López MC. Morbilidad en el recién nacido con fetopatía diabética. Rev Med IMSS. 2002;40(1):5-10.

  11. Ugalde-Fernámdez JH, Valdés-Garza H, Urtiaga- Silva MI. Frecuencia de miocardiopatía en neonatos de mujeres diabéticas. Rev Mex Pediatr. 1999;66 (1):9-13.

  12. Hay WW Jr. Care of the Infant of Diabetic Mother. Curr Diab Rep. 2012;12(1):4-15.

  13. Ullmo S, Vial Y, DiBernardo S, Roth-Kleiner M, Mivelaz Y, Sekarski N, et al. Pathologic ventricular hypertrophy in the offpring of diabetic mothers: a retrospective study. Eur Heart J. 2007;28(11):1319-1325.

  14. Hinojosa-Cruz JC, San Luis-Miranda R, Veloz- Martínez MG, Puello-Tamara E, Arias-Monroy LG, Barra-Urrutia A, et al. Diagnóstico y frecuencia de cardiopatía fetal mediante ecocardiografía en embarazos con factores de alto riesgo. Ginecol Obstet Mex. 2006;74(12):645-656.

  15. Kafle P, Ansari MA, Khanal U. Fetal Cardiac Interventricular Septal Thickness at 28-37 weeks of gestation in Nepalese population. NJR. 2012;2(2):36-42.

  16. Yánez-Sánchez JM, Hinojosa-Pérez JO. Prevalencia de hipertrofia del septum interventricular en el recién nacido macrosómico. AVANCES. 2004;2(4):22-23.

  17. Tabib A, Shirzad N, Sheikhbahaei S, Mohammadi S, Qourbani M, Haghpanah V, et al. Cardiac Malformations in Fetuses of gestational and pre-gestational diabetic mothers. Iran J Pediatr. 2013;23(6):664-668.

  18. Reece EA, Homko CJ. Infant of Diabetic Mother. Semin Perinatol. 1994;18(5):459-469.

  19. Wren C, Birrell G, Hawthorne G. Cardiovascular malformations in infants of diabetic mothers. Heart. 2003;89(10):1217-20.

  20. Gonzalez AB, Young L, Doll JA, Morgan GM, Crawford SE, Plunkett BA. Elevated neonatal insulin-like growth factor I is associated with fetal hipertrophic cardiomyopathy in diabetic women. Am J Obstet Gynecol. 2014;211(3):290.e1-7.

  21. Nizard J, Ville Y. The fetus of a diabetic mother: sonographic evaluation. Semin Fetal Neonatal Med. 2009;14(2):101-105.

  22. Abu-Sulaiman RM, Subaih B. Congenital heart disease in infants of diabetic mothers: echocardiographic study. Pediatr Cardiol. 2004;25(2):137-40.

  23. Díaz-Duran S. Diagnóstico prenatal de miocardiopatía hipertrófica septal en hijos de madres diabéticas a través de estudio ecocardiográfico fetal y su relación con los valores de hemoglobina glicosilada materna. Rev Guatem Cardiol. 2014;24(1):12-14.

  24. Nashaat EH, Mansour GM. Uncontrolled diabetes mellitus and Fetal Heart. Researcher. 2010;2 (5):45-55.

  25. Russell NE, Foley M, Kinsley BT, Firth RG, Coffey M, McAuliffe FM. Effect of pregestational diabetes mellitus on fetal cardiac function and structure. Am J Obstet Gynecol. 2008;199(3):312e1-312e7.

  26. Lydia MR, Drose JA. Cardiomiopatías Fetales. En: Drose JA. Ecocardiografía Fetal. 2a ed. Caracas, Venezuela: Amolca; 2011. p. 293-305.

  27. Crispi-Brillas F, Cruz-Lemini M, Gómez-del Rincón O. Miocardiopatías. En: Galindo-Izquierdo A, Gratacós- Solsona E, Marínez-Crespo JM. Cardiología Fetal. Madrid, España: Marbán; 2015. p. 428-434.

  28. Fetal Echocardiography Task Force, American Institute of Ultrasound in Medicine Clinical Standards Committee, American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine , American College of Radiology. AIUM practice guideline for the performance of fetal echocardiography. J Ultrasound Med. 2011;30(1):127-136.

  29. American Society of Echocardiography. American Society of Echocardiography Guidelines and Standards for Performance of the Fetal Echocardiogram. J Am Soc Echocardiogr. 2004;17(7):803-810.

  30. El-Ganzoury MM, El-Masry SA, El-Farrash RA, Anwar M, Abd-Ellatife RZ. Infants of diabetic mothers: echocardiographic measurements and cord blood IGF-I and IGFBP-1. Pediatric Diabetes. 2012;13(2): 189-196.

  31. Huang TT, Kelly A, Becker SA, Cohen MS, Stanley CA. Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism. Arch Dis Child Fetal Neonatal Ed. 2013;98(4):F351-F354.

  32. Arslan D, Oran B, Vatansev H, Cimen D, Guvenc O. The usefulness of plasma asymmetric dimethylarginine (ADMA) levels and tissue Doppler echocardiography for heart function in term infants born to mothers with gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2013;26(17):1742-8.

  33. Eslamian L, Akbari S, Marsoosi V, Jamal A. Association between fetal overgrowth and metabolic parameters in cord blood of newborns of women with GDM. Minerva Med. 2013;104(3):317-324.

  34. Madsen NL, Schwartz SM, Lewin MB, Mueller BA. Prepregnancy body mass index and congenital heart defects among offspring: a population-based study. Congenit Heart Dis. 2013;8(2):131-141.

  35. Cheng X, Chapple SJ, Patel B, Puszyk W, Sugden D, Yin X, et al. Gestational diabetes mellitus impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes. 2013;62(12):4088-4097.

  36. Pisaneschi S, Boldrini A, Genazzani AR, Coceani F, Simoncini T. Feto-placental vascular dysfunction as a prenatal determinant of adult cardiovascular disease. Intern Emerg Med. 2013;8(Suppl 1):S41-45.

  37. Goulopoulou S, Hannan JL, Matsumoto T, Ergul A, Webb RC. Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: implications for vascular adaptations to pregnancy. Am J Physiol Heart Circ Physiol. 2014;306(4):H610-618.

  38. Sharland G. Routine fetal cardiac screening: what are we doing and what should we do? Prenat Diagn. 2004;24(13):1123-9.

  39. Meyer-Wittkopf M, Simpson JM, Sharland GK. Incidence of congenital heart defects in fetuses of diabetic mothers: a retrospective of 326 cases. Ultrasound Obstet Gynecol. 1996;8(1):8-10.




2020     |     www.medigraphic.com