2005, Number 5
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Rev Mex Urol 2005; 65 (5)
Positive fragments in prostate biopses percentage and its relation with the positive surgical margins in patients submitted to radical prostatectomy in Hospital General “Dr. Manuel Gea González”
Soel EJM, Solares SME, Morales MG, Pérez OR, Pacheco GC, Parraguirre MS, Pilar MM, Calderón FF
Language: Spanish
References: 17
Page: 331-335
PDF size: 67.43 Kb.
ABSTRACT
Preceding. The prostate cancer is the second one tumor common in the man. It is esteemed 198,000 cases diagnosed annually and 80,000 patients are submitted to radical prostatectomy in USA. Approximately 30% has cancer in the margin of resection. Our objective is to know the relation of the percentage positive fragments in the biopsies of prostate with the margins surgical in patients submitted to radical prostatectomy.
Material and methods. Study retrospective, open, cross. Period of July 1991 to July 2004. Age is analyzed, antigen prostates, Gleason, positive biopsies, surgical margins, tumor volume. Statistical descriptive, “t” Student and analysis bivariate.
Results. Were included 65 patient, with negative margin 33 and positive 32. Age average 66.9 and 65.5 years respectively. Antigen prostates average of patients with positive margin 15.1 ng/mL (p = 0.033) and tumor volume of 45% (p = 0.012). 50% associate to greater risk of positive margins (p = 0.06).
Conclusions. Patient with but of the 50% of positive biopsies have high risk of positive margins, also are to a greater volume tumor.
REFERENCES
Greenlee RT, Hill-Harmon MB, Murray T, et al. Cancer statistics, 2001. CA Cancer J Clin 2001; 51: 15.
INEGI. Registro Histopatológico de Neoplasias en México, 1999.
Parker SL, Tong T, Bolden S, et al. Cancer statistics. CA Cancer J Clin 1997; 47: 5-27.
Steele G, Richie J. Understanding and Avoiding Positive Margins in Prostate cancer. AUA Update Series. Lesson 1 vol. XX. 2001: 2-7.
McNeal JE. Cancer volume and site of origin of adenocarcinoma in the prostate: relationship to local and distant spread. Hum Pathol 1992; 23: 258.
Blackwell KL, Bostwick DG, Myers RP, et al. Combining prostate specific antigen with cancer and gland volume to predict more reliably pathological state: the influence of prostate specific antigen cancer density. J Urol 1994; 151: 1565.
Terris MK, Haney DJ, Johnstone IM, et al. Prediction of prostate cancer volume using prostate-specific antigen levels, transrectal ultrasound, and systematic sextant biopsies. Urology 1995; 45: 75-80.
Borirakchanyavat S, Bhargava V, Shinohara K, et al. Systematic sextant biopsies in the prediction of extracapsular extension at radical prostatectomy. Urology 1997; 50: 373-8.
D’Amico AV, Whittington R, Malkowicz SB, et al. Clinical utility of the percentage of positive prostate biopsies in defining biochemical outcome after radical prostatectomy for patients with clinically localized prostate cancer. J Clin Oncol 2000; 18: 1164-72.
10.Catalona WJ, Smith DS. 5-year tumor recurrence rates after anatomical radical retropubic prostatectomy for prostate cancer. J Urol 1994; 152: 1837-42.
11.Humphrey PA, Vollmer RT. Percentage carcinoma measure of prostatic tumor size in radical prostatectomy tissues. Mod Pathol 1997; 10: 326.
12.Partin AW, Kattan MW, Subong EN, et al. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. JAMA 1997; 277: 1445-51.
13.Daniels GF, McNeal JE, Stamey TA. Predictive value of contralateral biopsies in unilaterally palpable prostate cancer. J Urol 1992; 174: 879-84.
14.Narayan P, Gajendran V, Taylor SP, et al. The role of transrectal ultrasound-guided antigen, and biopsy Gleason score in prediction of final pathologic diagnosis in prostate cancer. Urology 1996; 155: 1361-7.
15.Hunlad H, Hammerer P, Henke RP. Preoperative prediction of tumor heterogeneity and recurrence after radical prostatectomy for localized prostatic carcinoma with digital rectal, examination prostate, specific antigen and the results of 6 systematic biopsies. J Urol 1996; 155: 1344-7.
16.D’Amico AV, Whittinton R, Malkowics SB, et al. Calculated prostate cancer volume than 4.0 cm3 identifies patients with localized prostate cancer who have a poor prognosis following radical prostatectomy or external-bean radiation therapy. J Clin Oncol 1998; 16: 3094-100.
17.Tigrani V, Bhargava V, Shinohara K, Presti J. Number of positive systematic sextant biopsies predicts surgical margin status at radical prostatectomy. Urology 1999; 54: 689-93.