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2016, Number 3

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Rev Hosp Jua Mex 2016; 83 (3)

Inflamación y sepsis

Moreno-Eutimio MA

Language: Spanish
References: 25
Page: 86-91
PDF size: 168.45 Kb.


ABSTRACT

Sepsis is a sindrome of physiologic, pathologic ans biochemical abnormalities induced by infection, in which the immune system is altered in the fight back to contain and neutralize the infection. Despite advances in the management of septic patients, sepsis is still the second leading cause of death among patients in non-coronary ICUs. The pathogenesis of the sepsis syndrome is critically dependent on activation of the innate immune response. Innate immunity plays a direct role in the development of sepsis and is also crucial for the activation and modulation of later antigen-specific adaptive immune responses. Nearly all of the clinical manifestations of sepsis can be attributed to components of the innate immune responses. Understanding the complexity of early response to infection and inflammatory network with respect to innate immune response is required for the future development of therapeutic strategies that will effectively control infectious diseases. In this review, we focuses on the new and expanding field of innate immune activation by pathogen-responsive receptors and molecular aspect of inflammation in patients with sepsis.


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