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2016, Number 3

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Residente 2016; 11 (3)

Molecular and clinical aspects related to circulating growth differentiation factor 15 (GDF-15)

Guadiana-Lozano R, Mendoza-Vázquez G, González-Sánchez AG, Zavala-Cerna G, Espinoza-Gómez F, Nava-Zavala AH

Language: Spanish
References: 26
Page: 111-119
PDF size: 302.70 Kb.


ABSTRACT

The growth differentiation factor 15 (GDF-15) is a growth factor that belongs to the superfamily of transforming growth factor β (TGF-β). It is present in different tissues, but above all, it is found abundantly in the placenta. Among its functions, the most important is the regulation of inflammation and apoptosis in injured tissues and during illness processes. However, the different signals transmitted via GDF-15 may vary on physiological and pathological conditions, having an opposite behavior, similar to that in the TGF-β family. It has been proven that it performs several functions on different pathologies, including inflammation, cancer, cardiovascular diseases and obesity. The serum levels of GDF-15 work as severity and progression markers in different diseases, and it could be implicated in the treatment of some of them.


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