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ISSN 2992-779X (Electronic)
ISSN 2007-6452 (Print)

2016, Number 3

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Investigación en Discapacidad 2016; 5 (3)

Genetic polymorphisms of the ROMO1 intronic regions are not associated with the development of knee osteoarthritis

Blancas-Meza CF, Martínez-Nava G, López-Reyes A, Zamudio-Cuevas Y, Martínez-Flores K, Clavijo-Cornejo D, Miranda-Labra R, Gutiérrez-Ruíz MC, Gómez-Quiroz LE, Pineda C, Fernández-Torres J

Language: Spanish
References: 31
Page: 139-145
PDF size: 209.78 Kb.


ABSTRACT

Osteoarthritis (OA) is a degenerative disorder that is characterized by articular cartilage breakdown, osteophytes formation, and subchondral bone sclerosis; its development and progression are mediated by proinflammatory mediators, as well as by reactive oxidative species (ROS). Recently there has been identified a mitochondrial protein called Romo1 that modulates ROS in different states of oxidative stress, and which is encoded by the gene ROMO1. This gene has single nucleotide polymorphisms (SNPs) that could affect the translation of the different isoforms of its associated protein, and it is unknown whether these could have implications in the modulation of ROS in patients with OA. The aim of this work was evaluate two polymorphisms of ROMO1 gene in samples of patients with knee OA. We found that the analyzed polymorphisms are not associated with the presence of OA, therefore are not useful markers for genetic studies of OA in Mexican population.


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