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2004, Number 1

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Rev Med Inst Mex Seguro Soc 2004; 42 (1)

Kidney Function in Patients with Type 2 Diabetes, Determined by Cockcroft-Gault Formula and Creatinine Clearance

Leyva JR, Álvarez AC, López MMG

Language: Spanish
References: 26
Page: 5-10
PDF size: 181.31 Kb.


ABSTRACT

Objective: our objective was to measure renal function with the glomerular filtration rate (GFR) determined by the Cockcroft-Gault formula vs. creatinine clearance from 24-h urine collection.
Design: this was a comparative transversal trial.
Materials and methods: seventy one patients with type 2 diabetes mellitus were enrolled in the study. In all patients, we determined GFR with Cockcroft-Gault formula and creatinine clearance. Mean difference between these two methods was analyzed with paired-sample Student t test and correlation was evaluated by Pearson correlation coefficient. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of Cockcroft-Gault formula were estimated.
Results: mean GFR obtained with Cockcroft-Gault formula was 87.65 ± 26.29 mL/min, and GFR with creatinine clearance was 84.57 ± 33.59 mL/min, (p = 0.384). There was a positive correlation between the two methods (r = 0.533, p < 0.0001). Sensitivity and specificity of Cockcroft-Gault equation were 70 and 50 %, respectively. PPV was 64 and NPV, 50 %.
Conclusions: Cockcroft-Gault equation is an easy, reliable, and rapid method to indirectly measure GFR in patients with type 2 diabetes mellitus.



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