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2016, Number 3

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Rev Mex Patol Clin Med Lab 2016; 63 (3)

Procalcitonin and neonatal sepsis: clinical and laboratory aspects

Sánchez-Garduño J

Language: Spanish
References: 28
Page: 148-154
PDF size: 291.21 Kb.


ABSTRACT

Sepsis and its implications remain a constant challenge for the physician; despite the technological advances and understanding of the pathophysiology, diagnosis remains difficult, particularly in newborn patients. Neonatal sepsis is one of the leading causes of death as reported by the World Health Organization for the years 2005 and 2010, even when the development and understanding of diagnostic and prognostic markers such as procalcitonin have facilitated early diagnosis, management and proper prognosis in recent years. Multiple studies support the use of procalcitonin in the diagnosis of neonatal sepsis, particularly when sepsis is late (after 72 hours of birth), and recommend cutoffs ranging from 0.5 to 2.4 ng/mL, diagnostic sensitivities reaching up 97% and specificities close to 94%. The usefulness of procalcitonin is still debatable; however, its use in conjunction with other markers is essential in the evaluation of patients with suspected neonatal sepsis.


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