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2016, Number 4

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Gac Med Mex 2016; 152 (4)

Glucotransporters: clinical, molecular and genetic aspects

Sandoval-Muñiz RJ, Vargas-Guerrero B, Flores-Alvarado LJ, Gurrola-Díaz CM

Language: Spanish
References: 75
Page: 547-557
PDF size: 753.32 Kb.


ABSTRACT

Oxidation of glucose is the major source of obtaining cell energy, this process requires glucose transport into the cell. However, cell membranes are not permeable to polar molecules such as glucose; therefore its internalization is accomplished by transporter proteins coupled to the cell membrane. In eukaryotic cells, there are two types of carriers coupled to the membrane: 1) cotransporter Na+-glucose (SGLT) where Na+ ion provides motive power for the glucose´s internalization, and 2) the glucotransporters (GLUT) act by facilitated diffusion. This review will focus on the 14 GLUT so far described. Despite the structural homology of GLUT, different genetic alterations of each GLUT cause specific clinical entities. Therefore, the aim of this review is to gather the molecular and biochemical available information of each GLUT as well as the particular syndromes and pathologies related with GLUT´s alterations and their clinical approaches.


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