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2016, Number 3

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Gac Med Mex 2016; 152 (3)

Utility of bone marrow biopsy in the diagnosis of myeloproliferative neoplasm

Tovar-Bobadilla JL, Ortiz-Hidalgo C

Language: Spanish
References: 35
Page: 407-418
PDF size: 982.47 Kb.


ABSTRACT

A diagnostic approach of myeloproliferative neoplasms, according to the 2008 WHO classification system for hematological malignancies, has to consider clinical, molecular, and cytogenetic information as well as bone marrow histology. A diagnosis of chronic myeloid leukemia requires the presence of BCR-ABL-1, and the Philadelphia chromosome-negative (Ph-1-negative) myeloproliferative neoplasms constitute three main subtypes, including primary myelofibrosis, polycythemia rubra vera, and essential thrombocythemia. These three Ph-1-negative myeloproliferative neoplasms share many pathogenic characteristic such as JAK2 mutations; however, they differ in prognosis, progression to myelofibrosis, and risk of leukemic transformation. There are currently various major points of interest in bone marrow examination in myeloproliferative neoplasms. One is the morphology of megakaryocytes, which are the hallmark of Ph-1-negative myeloproliferative neoplasms and play a crucial role in separating the different subtypes of myeloproliferative neoplasms. Another is reticulin fibrosis or collagen fibrosis, which may only be detected on a bone marrow biopsy specimen by reticulin and trichrome stains, respectively, and immunohistochemistry and certain molecular techniques may be applied in bone marrow biopsies as supporting evidence of certain features of myeloproliferative neoplasms.


REFERENCES

  1. Madelung AB, Bondo H, Stamp I, et al. World Health Organization-defined classification of myeloproliferative neoplasms: morphological reproducibility and clinical correlations--the Danish experience. Am J Hematol. 2013;88:1012-6.

  2. Stein BL, Gotlib J, Arcasoy M, et al. Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. J Natl Compr Canc Netw. 2015;13:424-34.

  3. Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951;6:372-5.

  4. Steensma DP. The chronic myeloproliferative disorders: An historical perspective. Curr Hematol Rep. 2003;2:221-30.

  5. Vardiman JW, Thiele J, Aber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemias: Rationale and important changes. Blood. 2009;114:937-51.

  6. Thiele J. Philadelphia Chromosome-Negative chronic myeloproliferative disease. Am J Clin Pathol. 2009:132:261-80.

  7. Kortezky GA. The legacy of the Philadelphia chromosome. J Clin Invest. 2007;117:2030-2.

  8. Zhang SP, Li H, Lai RS. Detection of JAK2 V617F mutation increases the diagnosis of myeloproliferative neoplasms. Oncol Lett. 2015;9:735-8.

  9. Hajdu SI. The Discovery of Blood Cells. A Note from History. Ann Clin Lab Sci. 2003;33:237-8.

  10. Izaguirre-Ávila R. El descubrimiento de las plaquetas. Rev Biomed. 1997;8:197-208.

  11. Cooper B. The origins of bone marrow as the seedbed of our blood: from antiquity to the time of Osler. Proc (Bayl Univ Med Cent). 2011;24: 115-8.

  12. Bittencourt RI, Vassallo J, Chauffaille M de L, et al. Philadelphia-negative chronic myeloproliferative neoplasms. Rev Bras Hematol Hemoter. 2012;34:140-9.

  13. Pozdnyakova O, Hasserjian RP, Verstovsek S, Orazi A. Impact of Bone Marrow Pathology on the Clinical Management of Philadelphia Chromosome- Negative Myeloproliferative Neoplasms. Clin Lymphoma Myeloma Leuk. 2015;15:253-61.

  14. Ortiz-Hidalgo C, Lara Torres CO. Interpretación de la biopsia de médula ósea: El informe histopatológico básico. Rev Latinoamer Patol. 2004;42:39-49.

  15. Kremer M, Quintanilla-Martínez L, Nährig J, von Schilling C, Fend F. Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis. Virchows Arch. 2005;447:920-37.

  16. Thiele J, Kvasnicka HM, Facchetti F, Franco V, van der Walt J, Orazi A. European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica. 2005;90:1128-32.

  17. Michiels JJ, De Raeve H, Hebeda K, et al. WHO bone marrow features and European clinical, molecular, and pathological (ECMP) criteria for the diagnosis of myeloproliferative disorders. Leuk Res. 2007;31:1031-8.

  18. Barbui T, Thiele J, Vannucchi AM, Tefferi A. Rethinking the diagnostic criteria of polycythemia vera. Leukemia. 2014;28:1191-5.

  19. Sun T. BCR-ABL1 negative myeloproliferative neoplasia. En: Flow cytometry, immunohistochemistry and molecular genetics for hematologic neoplasms. 2a ed. Lippincot Williams & Wilkins; 2012. pp. 69-77.

  20. Kim SY, Im K, Park SN, Kwon J, Kim JA, Lee DS. CALR, JAK2, and MPL Mutation Profiles in Patients with Four Different Subtypes of Myeloproliferative Neoplasms: Primary Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera, and Myeloproliferative Neoplasm, Unclassifiable. Am J Clin Pathol. 2015;143:635-44.

  21. Cashell AW, Buss DH. The frequency and significance of megakaryocytic emperipolesis in myeloproliferative and reactive states. Ann Hematol. 1992;64:273-6.

  22. Thiele J, Kvasnicka HM, Zankovich R, Diehl V. Relevance of bone marrow features in the differential diagnosis between essential thrombocythemia and early stage idiopathic myelofibrosis. Haematologica. 2000;85:1126-34.

  23. Pozdnyakova O, Rodig S, Bhandarkar S, Wu K, Thiele J, Hasserjian R. The importance of central pathology review in international trials: a comparison of local versus central bone marrow reticulin grading. Leukemia. 2015;29:241-4.

  24. Thiele J, Kvasnicka HM, Tefferi A, et al. Primary myelofibrosis: En: Sweldon SH, Campo E, Harris NL, et al. eds. WHO classification of Tumors of Hematopoyetic and Lymphoid Tissues. 4.a ed. Lyon, France: IARC Press; 2008. pp. 44-7.

  25. Kreipe H, Büsche G, Bock O, Hussein K. Myelofibrosis: molecular and cell biological aspects. Fibrogenesis Tissue Repair. 2012;5(Suppl 1): S21-6.

  26. Kuter DJ, Bain B, Mufti G, Bagg A, Hasserjian RP. Bone marrow fibrosis: pathophysiology and clinical significance of increase bone marrow stromal fibres. Br J Haematol. 2007;139:351-62.

  27. Campregher PV, Santos FP, Perini GF, Hamerschlak N. Molecular biology of Philadelphia-negative myeloproliferative neoplasms. Rev Bras Hematol Hemoter. 2012;34:150-5.

  28. Campregher PV. Does angiogenesis matter in primary myelofibrosis? Rev Bras Hematol Hemoter. 2014;36:311-2.

  29. Malhotra J, Kremyanskaya M, Schorr E, Hoffman R, Mascarenhas J. Coexistence of myeloproliferative neoplasm and plasma-cell dyscrasia. Clin Lymphoma Myeloma Leuk. 2014;14:31-6.

  30. Medinger M, Passweg J. Angiogenesis in myeloproliferative neoplasms, new markers and future directions. Memo. 2014;7:206-10.

  31. Kitamura T, Inoue D, Okochi-Watanabe N, et al. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 2014;90:389-404.

  32. Cervantes F, Urbano-Ispizua A, Villamor N, et al. Ph-positive chronic myeloid leukemia mimicking essential thrombocythemia and terminating into megakaryoblastic blast crisis: report of two cases with molecular studies. Leukemia. 1993;7:327-30.

  33. León-Martínez G, Ortiz-Hidalgo C. Utilidad de la biopsia de médula ósea en el diagnóstico de síndromes mielodisplásicos. Patología Rev Latinoam. 2015;53:55-67.

  34. Büsche G, Majewski H, Schlué J, et al. Frequency of pseudo-Gaucher cells in diagnostic bone marrow biopsies from patients with Ph-positive chronic myeloid leukaemia. Virchows Archiv. 1997;430:139-48.

  35. Pardanani A, Tefferi A, Litzow MR, et al. Chronic myeloid leukemia with p190BCR-ABL: prevalence, morphology, tyrosine kinase inhibitor response, and kinase domain mutation analysis. Blood. 2009;114:3502-3.




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