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2016, Number 2

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Residente 2016; 11 (2)

Trombosis venosa profunda y tromboembolia pulmonar en pacientes con cáncer colorrectal

Cabrales-Escobar IE, Zermeño-González ML, Nava-Zavala AH, Rubio-Jurado B

Language: Spanish
References: 56
Page: 60-70
PDF size: 301.92 Kb.


ABSTRACT

Since the publication of «Clinique Médicale de l’Hôtel-Dieu de Paris» by Trousseau in 1865, an important link between malignancy and hypercoagulable states has been established. Thrombosis is often diagnosed as the first clinical manifestation of a tumour and the second leading cause of death of patients with cancer. Moreover, various authors have demonstrated a significant correlation between the incidence of thromboembolic events and a worse prognosis of neoplastic disease. There are multiple factors that influence the incidence of thrombosis: advanced disease, presence of a central catheter, chemotherapy, type of tumor, surgery, among other. Despite a long-recognized association between cancer and thrombosis, few data are available regarding the incidence of venous thromboembolism among patients with specific types of cancer, such as colorectal cancer. The objective of this review was to describe the incidence, disease course, risk factors, and prognosis associated with venous thromboembolism in patients with colorectal cancer. Activated coagulation and cancer tissue form a mutual positive-feedback loop, and strategies that interfere with this loop may be an interesting new strategy for cancer and thromboembolism prevention or treatment.


REFERENCES

  1. Frere C, Debourdeau P, Hij A et al. Therapy for cancer-related thromboembolism. Semin Oncol. 2014; 41 (3): 319-338.

  2. Trousseau A. Phlegmasia alba dolens. Clin Med Hôtel-Dieu Paris. 1865; 654-712.

  3. Mandalà M1, Ferretti G, Cremonesi M, Cazzaniga M, Curigliano G, Barni S. Venous thromboembolism and cancer: new issues for an old topic. Crit Rev Oncol Hematol. 2003; 48 (1): 65-80.

  4. Lima LG, Monteiro RQ. Activation of blood coagulation in cancer: implications for tumour progression. Biosci Rep. 2013; 33 (5): pii: e00064.

  5. Hoffman R, Haim N, Brenner B. Cancer and thrombosis revisited. Blood Rev. 2001; 15 (2): 61-67.

  6. Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007; 5 (3): 632-634.

  7. Degen JL, Palumbo JS. Hemostatic factors, innate immunity and malignancy. Thromb Res. 2012; 129 (1): S1-S5.

  8. Van den Berg YW, Osanto S, Reitsma PH, Versteeg HH. The relationship between tissue factor and cancer progression: insights from bench and bedside. Blood. 2012; 119 (4): 924-932.

  9. Dutia M, White RH, Wun T. Risk assessment models for cancer-associated venous thromboembolism. Cancer. 2012; 118 (14): 3468-3476.

  10. Khorana AA, Francis CW, Culakova E et al. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer. 2007; 110 (10): 2339-2346.

  11. Catalano O, Nunziata A, de Lutio di Castelguidone E, d’Errico AG. Thrombosis and cancer: spectrum of multidetector CT findings in oncologic patients with thromboembolic disease. A pictorial review. Acta Radiol. 2011; 52 (7): 730-737.

  12. Debourdeau P, Farge D, Beckers M et al. International clinical practice guidelines for the treatment and prophylaxis of thrombosis associated with central venous catheters in patients with cancer. J Thromb Haemost. 2013; 11 (1): 71-80.

  13. Verso M, Agnelli G. Venous thromboembolism associated with long-term use of central venous catheters in cancer patients. J Clin Oncol. 2003; 21: 3665-3675.

  14. Farge D, Durant C, Villiers S et al. Lessons from French National Guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients. Thromb Res. 2010; 125 (Suppl 2): S108-S116.

  15. Monreal M, Falgá C, Valdés M et al. Fatal pulmonary embolism and fatal bleeding in cancer patients with venous thromboembolism: findings from the RIETE registry. J Thromb Haemost. 2006; 4 (9): 1950-1956.

  16. Falanga A, Zacharski L. Deep vein thrombosis in cancer: the scale of the problem and approaches to management. Ann Oncol. 2005; 16 (5): 696-701.

  17. Heit JA, Silverstein MD, Mohr DN et al. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000; 160 (6): 809-815.

  18. Sorensen HT, Mellemkjaer L, Olsen JH et al. Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 2000; 343 (25): 1846-1850.

  19. Farge-Bancel D, Bounameaux H, Brenner B, Büller HR, Kakkar A, Pabinger I et al. Implementing thrombosis guidelines in cancer patients: a review. Rambam Maimonides Med J. 2014; 5 (4): e0041.

  20. Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH. Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy. Thromb Res. 2010; 126 (2): 113-118.

  21. Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003; 107 (Suppl 1): I9-16.

  22. Salama P. Thrombosis and cancer. An Sist Sanit Navar. 2004; 27 (Suppl 3): 45-51.

  23. Elyamany G, Alzahrani AM. Cancer-associated thrombosis: an overview. Clin Med Insights Oncol. 2014; 8: 129-137.

  24. Falanga A, Rickles F. Pathophysiology of the thrombophilic state in cancer patients. Semin Thromb Haemost. 1999; 25 (2): 173-182.

  25. Molnar S, Guglielmone H, Lavarda M, Rizzi ML, Jarchum G. Procoagulant factors in patients with cancer. Acta Bioquím Clin Latinoam. 2006; 40 (4): 483-489.

  26. Eilestsen K, Osterud B. Tissue factor: (patho)physiology and cellular biology. Blood Coagul Fibrinolysis. 2004; 15 (7): 521-538.

  27. Tormoen GW, Haley KM, Levine RL, McCarty OJ. Do circulating tumor cells play a role in coagulation and thrombosis? Front Oncol. 2012; 2: 115.

  28. Rickles FR, Falanga A. Molecular basis for the relationship between thrombosis and cancer. Thromb Res. 2001; 102 (6): V215-524.

  29. Felding-Habermann B. Tumor cell-platelet interaction in metastasis disease. Haemostasis. 2001; 31 (Suppl 1): 55-58.

  30. Aharon A, Brenner B. Microparticles, thrombosis and cancer. Best Pract Res Clin Haematol. 2009; 22 (1): 61-69.

  31. Davila M, Amirkhosravi A, Coll E, Desai H, Robles L, Colon J et al. Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation. J Thromb Haemost. 2008; 6 (9): 1517-1524.

  32. Thodiyil PA, Kakkar AK. Variation in relative risk of venous thromboembolism in different cancers. Thromb Haemost. 2002; 87 (6): 1076-1077.

  33. Chew H, Wun T, Harvey D et al. The incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med. 2006; 166 (4): 458-464.

  34. Walker AJ, West J, Card TR, Humes DJ, Grainge MJ. Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England. J Thromb Haemost. 2014; 12 (5): 641-649.

  35. Alcalay A, Wun T, Khatri V, Chew HK, Harvey D, Zhou H et al. Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival. J Clin Oncol. 2006; 24 (7): 1112-1118.

  36. Hanna N, Bikov KA, McNally D, Onwudiwe NC, Dalal M, Mullins CD. Impact of venous thromboembolism on mortality of elderly medicare patients with stage III colon cancer. Oncologist. 2012; 17 (9): 1191-1197.

  37. Toledano TH, Kondal D, Kahn SR, Tagalakis V. The occurrence of venous thromboembolism in cancer patients following major surgery. Thromb Res. 2013; 131: 1-5.

  38. Xie YZ, Fang KF, Ma WL, Shi ZH, Ren XQ. Risk of postoperative deep venous thrombosis in patients with colorectal cancer treated with open or laparoscopic colorrectal surgery: A meta-analysis. Indian J Cancer. 2014; 51 (Suppl 2): e42-44.

  39. Gould MK, Garcia DA, Wren SM et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141: e227S-277S.

  40. Ay C, Pabinger I. Predictive potential of haemostatic biomarkers for venous thromboembolism in cancer patients. Thromb Res. 2012; 129 (Suppl 1): S6-S9.

  41. Ahern TP, Horváth PE, Spindler KL, Sorensen HT, Ording AG, Erichsen R. Colorectal cancer, comorbidity, and risk of venous thromboembolism: assessment of biological interactions in a Danish nationwide cohort. Br J Cancer. 2016; 114: 96-102.

  42. Kawai K, Kitayama J, Tsuno NH, Sunami E, Nagawa H. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. Int J Colorectal Dis. 2011; 26 (1): 45-51.

  43. Kawai K, Kitayama J, Tsuno NH, Sunami E, Watanabe T. Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer. Int J Colorectal Dis. 2013; 28 (4): 527-535.

  44. Scappaticci FA, Skillings JR, Holden SN et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst. 2007; 99 (16): 1232-1239.

  45. Schutz FA, Je Y, Azzi GR, Nguyen PL, Choueiri TK. Bevacizumab increases the risk of arterial ischemia: a large study in cancer patients with a focus on different subgroup outcomes. Ann Oncol. 2011; 22 (6): 1404-1412.

  46. Nalluri SR, Chu D, Keresztes R et al. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA. 2008; 300 (19): 2277-2285.

  47. Al-Shamsi HO, Al Farsi A, Anjum M, Shen H, Zbuk K, Cook RJ et al. Thrombotic events in metastatic colorectal cancer patients treated with leucovorin, fluorouracil and irinotican (FOLFIRI) plus bevacizumab. J Gastrointest Oncol. 2015; 6 (3): 274-279.

  48. Kommareddy A, Zaroukian MH, Hassouna HI. Upper extremity deep venous thrombosis. Semin Thromb Hemost. 2002; 28 (1): 89-99.

  49. Amer MH. Cancer-associated thrombosis: clinical presentation and survival. Cancer Manag Res. 2013; 5: 165-178.

  50. Huber O, Bounameaux H, Borst F, Rohner A. Postoperative pulmonary embolism after hospital discharge: an underestimated risk. Arch Surg. 1992; 127 (3): 310-313.

  51. Silva P, Rosales M, Milheiro MJ, Santos LL. Pulmonary embolism in ambulatory oncologic patients. Acta Med Port. 2015; 28 (4): 463-468.

  52. Kim J, Bae BN, Jung HS, Park I, Cho H, Gwak G et al. Risk factors of a pulmonary thromboembolism after colorectal surgery. Ann Coloproctol. 2015; 31 (5): 187-191.

  53. Iqba N, Sharma A. Cerebral venous thrombosis: a mimic of brain metastases in colorectal cancer associated with a better prognosis. Case Rep Oncol Med. 2013; 2013: 109412.

  54. Ozen A, Cicin I, Sezer A, Uzunoglu S, Saynak M, Genchellac H et al. Dural sinus vein thrombosis in a patient with colon cancer treated with FOLFIRI/bevacizumab. J Cancer Res Ther. 2009; 5 (2): 130-132.

  55. Sereno M, Montoro FJ, Casanova C, Gutiérrez GG, Ojeda J, Casado ES. An unusual cause of respiratory failure in a colon cancer patient. Mol Clin Oncol. 2015; 3 (5): 1152-1154.

  56. Gross CP, Galusha DH, Krumholz HM. The impact of venous thromboembolism on risk of death or hemorrhage in older cancer patients. J Gen Intern Med. 2007; 22 (3): 321-326.




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