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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2005, Number 6

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Rev Invest Clin 2005; 57 (6)

The carcinoembryonic antigen:by the way a well-known friend

Téllez-Ávila FI, García-Osogobio SM

Language: Spanish
References: 39
Page: 814-819
PDF size: 152.57 Kb.


ABSTRACT

The carcinoembryonic antigen (CEA) is glycoprotein localized in the apical surface of mature enterocytes. The members of the CEA gene family are clustered on chromosome 19q13.2. It is formed by 29 genes, of which 18 are expressed. Many functions of CEA have been known in healthy individuals, however its role as cell adhesion molecule is the most studied. Besides the colon, CEA is expressed in the stomach, tongue, oesophagus, cervix, and prostate. The most important clinical function is in colorectal, gastric and ovary cancer. It is used as prognosis marker, staging system, recurrence, treatment response and liver metastases. There are many no neoplasic-diseases that enhance CEA value. Actually, the CEA is being studying as target of immunotherapy.


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