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Academia Mexicana de Neurología, A.C.

2015, Number 5

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Rev Mex Neuroci 2015; 16 (5)

Genetic alterations and cytogenetic tests related to mesial temporal lobe epilepsy

Guzmán-Jiménez DE, Velasco-Monroy AL

Language: Spanish
References: 50
Page: 39-47
PDF size: 231.31 Kb.


ABSTRACT

Epilepsy is a disease characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological and social consequences of this condition. Worldwide, about 1-2% of the population suffers epilepsy. In Mexico, epilepsy risk have been found to be 1.14% to 2.03%. Considering the national population, it is estimated between 10 and 20 million Mexicans with epilepsy. The mesial temporal lobe epilepsy corresponds to approximately to 65% of the subtypes of temporal lobe epilepsy. However, it has not been concretely determined if there exists any genetic disorder directly related to the disease; for this reason, different research groups have used microarray-based cytogenetic techniques, allowing them to propose some locus and candidate genes associated with the disease. In the near future, these techniques could be used as part of diagnostic protocol of this condition. This document is based on a review of the literature on the relationship between genetic alterations and temporal lobe epilepsy, as well as new cytogenetic techniques that might be useful as part of the diagnostic protocol.


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