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2016, Number 1

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Rev Esp Med Quir 2016; 21 (1)

Strategies for regeneration of corneal limbal epithelial stem cells

Téllez-González MA, Gutiérrez-Salinas J, Suárez-Cuenca JA, Mondragón- Terán P

Language: Spanish
References: 40
Page: 24-30
PDF size: 503.12 Kb.


ABSTRACT

The Limbal Epithelial Stem Cells (LESC´s) are unipotent Stem Cells that reside in the esclero-corneal limbus. Since the last decade it has been reported that these cells play an important role in the maintenance and regeneration of the cornea. The absence of these cells, derive in complications in the corneal tissue such as losing transparency, regenerative failure, including the presence of syndromes. The culture and derivation of LESC’s is a potential strategy for regenerative medicine: Once the optimal experimental conditions to generate a 3D LESC culture is established, these 3D constructs could be used as corneal substitutes in clinical trials.


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