2016, Number 1
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Med Int Mex 2016; 32 (1)
Results of the treatment of chronic venous ulcers with a polymer polysaccharide with zinc oxide
Cueto-García J, Moreno-Eutimio MA, Ibáñez-González VT, Rodríguez-Ayala E, Moreno-Rodríguez J
Language: Spanish
References: 30
Page: 48-57
PDF size: 826.90 Kb.
ABSTRACT
Background: Chronic varicose vein ulcers continue to represent a
challenge to the health systems worldwide mainly due to the fact that
they are very difficult to treat and that at the present time there is no
product or method really effective that improves healing, avoids complications
and improves the quality of life patients.
Objective: To evaluate the clinical and molecular results of the application
of a polymer polysaccharide with zinc oxide in the treatment
of chronic ulcers.
Material and Method: A clinical, open, experimental, longitudinal,
prospective, random study was done making a comparative evaluation
in two arms, in patients with chronic varicose vein ulcers, phase
III, during seven months. One group received polymer polysaccharide
with zinc oxide and control group was given conventional treatment
(external venous compression and simple bandage).
Results: Healing process of chronic varicose vein ulcers in the two
groups showed important differences: in group treated with polymer
polysaccharide with zinc oxide, chronic varicose vein ulcers showed
a significantly higher reduction of the area of the ulcer than that observed
in control group. In control group five unsatisfied patients with
the treatment abandoned the study during weeks 5 to 8, which was
not observed in group treated with polymer polysaccharide with zinc
oxide. These clinical findings showed a parallel course to the serum
levels of cytokines IL-8 and IL-6, lower of CD 45+ cells and increased
CD 31+ cells in group treated with polymer polysaccharide with zinc
oxide compared to control group.
Conclusions: Polymer polysaccharide with zinc oxide showed having
a very favorable effect on healing of chronic varicose vein ulcers,
accompanied by an evident improvement of life quality. It also produces
changes on serum levels of cytokines IL-8 and IL-6, lower of CD 45+
cells and increased CD 31 + cells.
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