Murillo OB, Pérez LEL, Malacara JM

Language: Spanish
References: 13
Page: 229-233
PDF size: 70.66 Kb.

ABSTRACT

Objective: To study the influence of ER-α on mammographic density.
Material and methods: We selected 87 healthy women (age 49.8 ± S.D. 6.12 years). We obtained the body mass index (BMI), and a fasting blood sample for hormone determinations and DNA extraction. ER-a genotyping was carried out by PCR and digestion with a PvuII and XbaI restriction endonucleases. Mammographic density was assigned by the radiologist used three categories of fatty, average and dense.
Results: Mammographic density was significantly associated with estradiol (p=0.04), estrone (p=0.04), and FSH (p=0.02).The BMI was not associated with PvuII and XbaI genotypes and marginally with mammographic breast density (p=0.06).
Conclusions: We did not observe compelling evidence of an association between variant alleles of genotypes estrogen receptors alpha and breast density.

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