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2015, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2015; 31 (4)

Antiphospholipid syndrome in women with recurrent pregnancy loss: laboratory diagnosis

Rodríguez PL, Castillo GD, Cabrera PY, Tejeda GM

Language: Spanish
References: 24
Page: 340-348
PDF size: 106.46 Kb.


ABSTRACT

The antiphospholipid syndrome is the most common type of acquired thrombophilia and is defined as a hypercoagulable state of autoimmune cause, which can provoke arterial and/or venous thrombosis, as well as a wide range of adverse obstetric complications associated to placental insufficiency. Among them are the recurrent pregnancy loss, stillbirth, early severe preeclampsia, intrauterine growth restriction, premature placental abruption and premature births. In general, in developing countries the magnitude of the problem caused by these antiphospholipid antibodies in women with recurrent pregnancy losses is high, as tests of elevated cost for the diagnosis of this disease are needed, which also requires qualified personnel for the interpretation of results and there is no uniformity in the laboratory criteria used for diagnosis by different institutions In Cuba we have diagnostic possibilities for the identification of these antiphospholipids which is a fundamental pillar in the differential analysis of this obstetric entity; therefore, the combination of an accurate diagnosis, careful monitoring and the proper treatment, guarantees pregnancy success.


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