Muñoz-Hernández E, Cerda-Téllez F, Huerta-Vargas D, Ramírez-Palma A, Suárez-Cuenca JA

Language: Spanish
References: 27
Page: 516-522
PDF size: 624.48 Kb.

ABSTRACT

Background: During processing and storage of red blood cells concentrates, some anticoagulants and additive agents are used as calcium chelators to extend the half-life of the product.
Objective: To evaluate the effect of transfusion of red blood cell concentrates on post-transfusion serum levels of calcium in patients with chronic liver disease (CLD).
Material and methods: A cross-sectional, prospective, quasiexperimental study was done with patients with CLD and anemic syndrome hospitalized in the Internal Medicine Department, Xoco General Hospital, Mexico City, during July 2014 to February 2015. Serum calcium was compared before and after one single red blood cells concentrate transfusion by analysis of mean differences.
Results: 33 males and 7 females, 51.1±12 years old were included. The score Child-Pugh-Turcotte was B (n=23) and C (n=17). The mean serum calcium levels pre-transfusion was 8.96±0.63 mg/dL, and posttransfusion was 8.77±0.81 mg/dL (p=0.13). The stratified exploring analysis showed a significant difference in the levels of calcium during pre-transfusion and post-transfusion period (9.02±0.47 vs 8.68±0.75 mg/dL; p=0.04) specifically in patients with Child-Pugh-Turcotte B. Also, higher reduction of post-transfusional calcium was associated with the use of blood products with longer storage time (cutoff 21 days) (% reduction in post-transfusional calcium packages ›21 storage days [5.02%±3.53] and ‹21 days [3.02%±2.49, p=0.03]).
Conclusions: The transfusion of red blood cell concentrates is related to calcium depletion, specifically in patients with CLD Child-Pugh-Turcotte B. Moreover, the storage time of the blood product has significant impact on the level of reduction of calcium.

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