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Colegio de Medicina Interna de México.

2015, Number 5

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Med Int Mex 2015; 31 (5)

Relation between triglycerides/HDLcholesterol index and fast altered glucose in normotensive patients with obesity and overweight

Hernández-Vite Y, Elizalde-Barrera CI, Flores-Alcántar MG, Vargas-Ayala G, Loreto-Bernal ML

Language: Spanish
References: 30
Page: 507-515
PDF size: 574.16 Kb.


ABSTRACT

Background: Currently within the scientific health research it has been established the importance of early identification and prevention of cardiovascular and metabolic entities. According to the pathophysiology of diabetes mellitus 2, this is a late submission of events that can be associated with metabolic syndrome, pathological condition related to insulin resistance and hyperinsulinemia which presents a high risk of developing type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Various diagnostic criteria have been established for metabolic syndrome, with modifications according to the type of population studied. These criteria include obesity, waist circumference, dyslipidemia, hyperglycemia and hypertension. Both the concentrations of HDLcholesterol (HDL-C) and triglyceride (TG) levels were independently associated with insulin sensitivity. Recently described the relationship between serum triglycerides (TG) and high density cholesterol (HDL-C) as marker comparable of insulin resistance, with the advantage of being simple, readily available tool. It’s necessary to establish parameters in order to identify in a timely and accessible way people whom are in early stages of insulin resistance, to make medical interventions and modify their prognosis. Thus, the triglycerides/HDL cholesterol (TG/HDL-C) ratio applied to patients who are suspected to have insulin resistancet would be useful in our population.
Objective: To determine the association between triglyceride/HDLcholesterol ratio (TG/HDL-C) and impaired fasting glucose in obese and overweight patients with normal blood pressure.
Material and method: A cross-sectional, descriptive, observational, and prolective study was done with a sample of 68 participants, 50% of these showed impaired fasting glucose while remaining 50% showed normal glucose, all patients were normotensive, obese or overweight and serum fasting glucose, triglycerides and total cholesterol, HDL and LDL were determined. Descriptive statistics were used to characterize the population. The inferential statistical analysis was performed using tests of association (odds ratio) and χ2 for dichotomous qualitative variables. Also p was calculated using T-test for continuous quantitative variables. It was considered a statistically significant difference with p ‹0.05.
Results: Of 68 patients, 48 were male. The average age was 41.13±11.70 years. Most patients (n=42) had elevated TG/HDL-C ratio. Were contrasted the independent variable (TG/HDL-C ratio) and dependent variable (impaired fasting glucose), finding a higher proportion of impaired fasting glucose in the group of patients with high TG/HDL-C. Assessment of association was made between TG/HDL-CL ratio (elevated or not) and impaired fasting glucose (present or absent) using the χ2 test which gave a value of 3.98 and a value of p=.046.
Conclusions: It was found a statistically significant association between the high TG/HDL-C ratio and the presence of impaired fasting glucose with a value of p‹.05, which was confirmed through odds ratio: OR=2.77 (95% CI 1.006, 7.673), concluding that the TG/HDL-C ratio is high risk factor for having impaired fasting glucose.


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