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2015, Number 1

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Rev Med UV 2015; 15 (1)

Células Troncales, Nicho y Biomateriales

Regalado SC, Tamariz E

Language: Spanish
References: 58
Page: 13-19
PDF size: 307.47 Kb.


ABSTRACT

Stem cells (SC) are characterized by their extensive potential of proliferation and differentiation, as well as their major role in homeostasis and tissue regeneration. In spite of SC are a promising source of cell replacement therapies and regeneration after injury or disease; its use is still limited because there are several issues that need to be taken into account, such as survival, tissue integration, specific differentiation and functionality. To consider them part of regenerative medicine it is imperative to understand their biology and niche or microenvironment found in vivo. The niche is constituted by cells, proteins and extracellular matrix which interact with the SC and may determine the undifferentiated or differentiation state into specific phenotypes. Furthermore, in recent years, the use of in vitro models that simulate various components of the niche have helped to begin to understand the role of factors that compose it, and even to design artificial models that recapitulate the conditions of a microenvironment. In that sense, biomaterials are an alternative to incorporate different physical and chemical properties that have been observed to modulate SC and to improve its manipulation. In this paper we review some of the strategies used for designing biomaterials in order to mimic the microenvironment of SC and to regulate their biology as well as the impact it may have in the future of tissue regeneration therapy with SC.


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