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2000, Number 4

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Rev Inst Nal Enf Resp Mex 2000; 13 (4)

Immunogenetic aspects of pulmonary tuberculosis.

Zúñiga RJA, Pérez LE, Quiroz V, Vargas-Alarcón G, García A, Olvera R, Navarro C, Camarena A, Granados J, Selman LM

Language: Spanish
References: 88
Page: 240-247
PDF size: 158.52 Kb.


ABSTRACT

Tuberculosis (TB) has a high rate of morbidity and accounts for approximately 3 million yearly deaths. M. tuberculosis infection studies have revealed the presence of determining environmental and genetic factors in the pathophysiology of TB. Some genes localized within the major histocompatibility complex (MHC), such as systems HLA and TNF-α among others have been associated to TB susceptibility in various ethnic groups. In the Mexican population, susceptibility to pulmonary TB is determined by the alleles HLA-DRBI 1501, HLA-DQAI 0101 and DQBI 0501. On the other hand, mutations in the IFN-g receptor 1 gene have been associated with lack of defense to mycobacterium infection. Furthermore, the receptor gene for vitamin D, the NRAMP-1 gene or the macrophage chemotactic protein gene (MCP-1) also seem to be related to genetic susceptibility or resistance to TB. Polymorphic genetic marker studies in TB are important to define the mechanisms of susceptibility to infection and of the clinical course of the disease.


REFERENCES

  1. WHO. Report on the TB epidemic. Geneva, Switzerland: WHO, 1994.

  2. WHO. Global tuberculosis control, communicable diseases. Geneva, Switzerland: WHO, 1999.

  3. WHO. What is DOTS?, A guide for understand the WHO-recommended TB control strategy known as DOTS. Geneva, Switzerland: WHO, 1999.

  4. Dirección General de Epidemiología/SSA. Sistema Nacional de Vigilancia Epidemiológica. Boletín No. 54, Vol. 17, semana 34, 20-26 de agosto 2000.

  5. Blackwell JM. Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in nothr-eastern Brazil. Int J Parasitol 1998; 28: 21-28.

  6. Hill AV. The immunogenetics of human infectious diseases. Annu Rev Immunol 1998; 16: 593-617.

  7. Goldfeld AE, Delgado JC, Thim S, Vivana BM, Uglialoro AM, Turbay D, et al. Association of an HLA-DQ allele with clinical tuberculosis. JAMA 1998; 279: 226-228.

  8. Rook GAW, Bloom BR. Tuberculosis, pathogenesis, protection and control. Washington DC: American Society for Microbiology Press, 1994: 485-501.

  9. Schluger NW, Rom WN. The host immune response to tuberculosis. Am J Respir Crit Care Med 1998; 157: 679.

  10. Ellner JJ. Review: the immune response in human tuberculosis- implications for tuberculosis control. J Infect Dis 1997; 176: 1351-1359.

  11. Stenger S, Modlin RL. T cell mediated immunity to Mycobacterium tuberculosis. Curr Opin Microbiol 1999; 2: 89.

  12. Stead WW, Senner JW, Reddick WT, Lofgren JP. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 1990; 322: 422-427.

  13. Nakamura RM, Tokunaga T. Strain difference of delayed type hypersensivity to BCG and its genetic control in mice. Infect Immun 1978; 1978: 657-664.

  14. Comstock GW. Tuberculosis in twins: a re-analysis of the prophit survey. Am Rev Respir Dis 1978; 117: 621-624.

  15. Bossik LJ. On the roles of hereditary and environment in the physiology and pathology of childhood tuberculosis. Proc Maxim Gorky Medico-Biological Res Inst (Moscow) 1934; 19: 111.

  16. Ravikumar M, Dheenadhayalan V, Rajaram K, Lakshmi SS, Kumaran PP, Paramasivan CN, et al. Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India. Tuber Lung Dis 1999; 79: 309-317.

  17. Dubaniewicz A. HLA-DR antigens in patients with pulmonary tuberculosis in northern Poland. Preliminary report. Arch Immunol Ther Exp 2000; 48: 47-50.

  18. McNicholl J. Host genes and infectious diseases. Emerg Infect Dis 1998; 4: 423-426.

  19. Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, et al. Tumor necrosis factor-a is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995; 2: 561-572.

  20. Bellamy R. Tuberculosis and chronic hepatitis B virus infection in africans and variation in vitamin D receptor gene. J Infect Dis 1999; 179: 721-724.

  21. Yamamura M. Cytokine patterns of immunologically mediated tissue damage. J Immunol 1992; 149: 1470.

  22. Sieling PA, Modlin RL. Cytokine pattern at the site of mycobacterial infection. Immunobiology 1994; 191: 378.

  23. Flores VPO, Chikunguwo SM, Harris TS, Stadecker MJ. Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responses in vitro and in vivo. J Immunol 1993; 151: 3192-3198.

  24. Bonecini Bonecini-Almeida MG. Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes. J Immunol 1998; 160: 4490.

  25. O’Brien L, Roberts B, Andrew PW. Activation of anti-mycobacterial activity of macrophages and mechanisms of anti-mycobacterial activity. Curr Top Microbiol Immunol 1995; 215: 97-124.

  26. Trinchieri G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr Opin Immunol 1997; 9: 17.

  27. Carter LL, Dutton RW. Type 1 and Type 2: a fundamental dichotomy for all cell subsets. Curr Opin Immunol 1996; 8: 336.

  28. Romagnani S. Lymphokine production by human T cells in disease states. Ann Rev Immunol 1994; 12: 227-257.

  29. Jouanguy E, Lamhamedi-Cherradi S, Lammas D, Dorman SE, Fondaneche SC, Dupuis S, et al. A human IFNGR1 small deletion associated with dominant susceptibility to mycobacterial infection. Nature Genet 1999; 4: 370.

  30. Newport MJ, Huxley CM, Huston S, Hawrlowicz CM, Oostra BA, Williamson BR, et al. A mutation in the interferon-g-receptor gene and susceptibility to micobacterial infection. N Engl J Med 1996; 335: 1941-1949.

  31. De Jong R, Altare F, Haagen IA, Elfernik DG, Boer T, Van Breda VPJ, et al. Severe mycobacterial and salmonella infections ininterleukin-12 receptor-deficient patients. Science 1998; 280: 1435.

  32. Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Diest F, et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998; 280: 1432.

  33. Trowsdale J, Ragousis J, Campell RD. Map of the human major histocompatibility complex (MHC). Immunol Today 1991; 12: 443-446.

  34. Beck S, Geraghty D, Inoko H, Rowen L. Complete sequence and gene map of a human major histocompatibility complex. Nature 1999; 401: 921-923.

  35. Nepom G, Nepom B. The major histocompatibility complex. In: Klippel J, Dieppl P, editors. Rheumatology. USA: Mosby, 1994: 12.1-12.2.

  36. Haynes BF, Pantaleo G, Fauci AS. Toward an understanding of the correlates of protective immunity to HIV infection. Science 1996; 271: 324-328.

  37. Taylor ML, Pérez MA, Yamamoto FJK, Granados J. Immunologic, genetic and social human risk factors associated to histoplasmosis: Studies in the state of Guerrero, Mexico. Mycopathologia 1997; 138: 137-141.

  38. Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN. Polymerase chain reaction-based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: Relevance to chemotherapy and disease severity. J Infect Dis 1996; 173: 669-676.

  39. Mitchison DA. Drug resisance in mycobacteria. Br Med Bull 1984; 40: 84-90.

  40. Khor M, Lowrie DB, Coates ARM, Mitchison DA. Recombinant interferon-g and chemotheraphy with isoniazid and rifampicin in experimental murine tuberculosis. Br J Exp Pathol 1986; 67: 587-596.

  41. Terán-Escandón D, Terán-Ortiz L, Camarena OA, González-Ávila G, Vaca-Marín MA, Granados J, et al. Human leukocyte antigen-associated susceptibility to pulmonary tuberculosis. Chest 1999; 115: 428-433.

  42. Brown JH, Jardetsky TS, Gorga JC. Three dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33-39.

  43. Stern LJ, Brown JH, Jardetzky. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994; 368: 215-221.

  44. Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989; 7: 625-655.

  45. Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, et al. Tumor necrosis factor (Cachectin) is an endogenous pyrogen and induces production of interleukin-1. J Exp Med 1986; 163: 1433-1450.

  46. Dayer JM, Beutler B, Cerami A. Cachectin/TNF stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 1985; 162: 2163-2168.

  47. Klebanoff SJ, Vadas MA, Harlan JA, Sparks LH, Gamble JR, Agnosti JM, et al. Stimulation of neutrophils by tumor necrosis factor. J Immunol 1986; 136: 4220-4222.

  48. Pfizenmaier K, Scheurich P, Schüter C, Krönke M. Tumor necrosis factor enhances HLA-A, B, C and HLA-DR genes expression in human tumor cells. J Immunol 1987; 183: 975-980.

  49. Kehr JH, Miller A, Fauci AS. Effect of tumor necrosis factor a on mitogen-activated human B cells. J Exp Med 1987; 166: 786.

  50. Yokota S, Geppert TD, Lipsky PE. Enhancement of antigen and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha. J Immunol 1988; 140: 531-536.

  51. Sung SS, Bjorndahl JM, Wang CY, Kao HT, Fu SM. Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody. J Exp Med 1988; 167: 937-953.

  52. Sung SS, Jung LKL, Walters JA, Chen W, Wang CY, Fu SM. Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med 1988; 168: 1539-1551.

  53. Spies T, Morton CC, Nedospasov SA, Fiers W, Pious D, Strominger JL. Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci USA 1986; 83: 8699-8704.

  54. Arnett FC. Genetic aspects of human lupus. Clin Immunol Immunopathol 1992; 63: 4-6.

  55. Jacob CO. Tumor necrosis factor a in autoimmunity: Pretty girl or old witch? Immunol Today 1992; 4: 122-125.

  56. Wilson AG, Di Giovine FS, Blakemore AIF, Duff GW. Single base polymorphism in the human tumor necrosis factor alpha (TNF-a) gene detectable by Ncol restriction of PCR product. Hum Mol Genet 1992; 1: 353.

  57. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 1997; 94: 3195-3199.

  58. Levin M, Newport MJ, D’Souza S, Kalabalikis P, Brown IN, Lenicker HN, et al. Familial dosseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene? Lancet 1995; 345: 79-83.

  59. Vidal SM, Pinner E, Lepage P, Gauthier S, Gros P. Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J Immunol 1996; 157: 3559.

  60. Cellier M, Prive G, Belouchi A, Kwan T, Rodrigues V, Chia W, et al. Nramp defines a family of membrane proteins. Proc Natl Acad Sci USA 1995; 92: 10089-10093.

  61. Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, et al. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med 1994; 180: 1741-1752.

  62. Liu J, Fujiwara TM, Buu NT, Sanchez FO, Cellier M, Paradis AJ, et al. Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet 1995; 56: 845.

  63. Braun MC, Lahey E, Kelsall BL. Selective suppression of IL-12 production by chaemoattractants. J Immunol 2000; 164: 3009-3017.

  64. Long GU, Tseng S, Horner RM. Control of Th2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000; 404: 407-411.

  65. Rutledge BJ, Rayburn H, Rosenberg R. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J Immunol 1995; 155: 4838-4843.

  66. Zlotnik A, Yoshie O. Chemokines: A new classification system and their role in immunity. Immunity 2000; 12: 121-127.

  67. Uguccioni M. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1a and MIP-1b on human monocytes. Eur J Immunol 1995; 25: 64-69.

  68. Opdenakker G, Pierre F, Nys G. The human MCP-3 gene (SCYA7): Cloning, sequence analysis, and assignment to the -cc chemokine gene cluster on chromosome 17q11.2-q12. Genomics 1994; 21: 403-408.

  69. Rovin BH, Lu L, Saxena R. A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Comun 1999; 259: 344-348.

  70. Lin Y, Gong J, Zhang M. Production of monocyte chemoattractant protein 1 in tuberculosis patients. Infect Immun 1998; 66: 2319-2232.

  71. Kashara K, Tobe T, Tomita M. Selective expression of monocyte chemotactic and activating factor/monocyte chemoattractant protein 1 in human blood monocytes by Mycobacterium tuberculosis. J Infect Dis 1994; 170: 1238-1247.

  72. Greelund AC, Farrar MA, Viviano BL, Schreiber RD. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system. EMBO J 1994; 13: 1591-1600.

  73. D’Souza S, Levin M, Faith A, Yssel H, Bennet B, Newport M, et al. Defective antigen processing associated with familial disseminated mycobacteriosis. Clin Exp Immunol 1996; 103: 35-39.

  74. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emile JF, Newport M, et al. Interferon-g receptor deficiency in an infant with fatal bacille Calmette-Guérin Infection. N Engl J Med 1996; 335: 1956-1961.

  75. Chan J, Kaufmann SHE. Immune mechanisms of protection. In: Bloom BR, editor. Tuberculosis: pathogenesis, protection ands control. Washington D.C: American Society for Microbiology Press, 1994; 389-415.

  76. Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 1993; 151: 518-525.

  77. Wong GH, Clark-Lewis I, McKimm-Breschkin L, Harris AW, Schrader JW. Interferon-g induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage and myeloid cell lines. J Immunol 1983; 131: 788-793.

  78. Nathan C. Nitric oxide as a secretory product of mammalian cells. EASEB J 1992; 6: 3051-3064.

  79. Walker L, Lowrie DB. Killing of Mycobacterium microti by immunologically activated macrophages. Nature 1981; 293: 69-71.

  80. Flesch IEA, Kaufmann SHE. Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 1990; 58: 2675.

  81. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon g gene-disrupted mice. J Exp Med 1993; 178: 2243-2247.

  82. Denis M. Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol. Clin Exp Immunol 1991; 84: 200-206.

  83. Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-g as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983; 158: 670-689.

  84. Rook GAW, Steele J, Fraher L. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986; 57: 159-163.

  85. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM. Retinoic X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 1992; 355: 446.

  86. Cippitelli M, Santoni A. Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur J Immunol 1998; 28: 3017.

  87. D’Ambrosio D, Cippitelli M, Cocciolo MG, Mazeo D, Di Lucia D, Lang R, et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-KappaB downregulation in transcriptional repression of p40 gene. J Clin Invest 1998; 101: 252.

  88. Roy S, Frodsham A, Hazra SK, Mascie-Taylor CG, Hill AV. Association of vitamin D receptor genotype with leprosy type. J Infect Dis 1999; 179: 187.




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