2015, Number 2
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Residente 2015; 10 (2)
Correlación entre el pH, anión-gap, gap de iones fuertes por fórmula de Stewart y de Gilfix en neonatos con trastornos metabólicos
Márquez-González H, Muñoz-Ramírez CM, Yáñez-Gutiérrez L, Almeida-Gutiérrez E, Ramírez-García MA
Language: Spanish
References: 12
Page: 58-62
PDF size: 213.94 Kb.
ABSTRACT
Using formulate to determine the anion gap is currently a useful tool in the interpretation of acid-base balance. There are many equations sustained by electroneutrality that have proven correlation with each other in adults. However, given the peculiarity of infants, these formulas can not show similarities.
Objective: To estimate the degree of correlation between pH, AG, and GIF by Stewart and Gilfix critically ill neonates.
Methods: In a prospective cohort of infants cared for in a neonatal intensive care a comparative study was conducted with laboratory blood gases and taken to income, with which were calculated by the following formulas: anion gap with and without the inclusion of potassium, strong ion gap formula of Stewart and Gilfix base difference. For statistical analysis, descriptive and inferential statistics were performed using Spearman correlation test and linear correlation with pH and formula Stewart. SPSS version 20 was used.
Results: The formulas were calculated on 146 blood gases, finding a statistically significant correlation with the formula of strong ion gaps with the anion gap, unlike real bases. The best way to predict units change equation Stewart was the base deficit.
Conclusions: Anion gap Gilfix formula and have good correlation with the Stewart.
REFERENCES
Jones NL. A quantitative physicochemical approach to acid-base physiology. Clin Biochem. 1990; 23 (3): 189-195.
Emmett M, Nairns RG. Clinical use of anion gap. Medicine (Baltimore). 1977; 56 (1): 38-54.
Figge J, Jabor A, Kazda A, Fencl V. Anion gap and hypoalbuminemia. Crit Care Med. 1998; 26: 1807-1810.
Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol. 1983; 61 (12): 1444-1461.
Gilfix BM, Bique MN, Magder S. A physical chemical approach to the analysis of acid-base balance in the clinical setting. J Crit Care. 1993; 8 (4): 187-197.
Moviat M, Pickkers PHJ, van der Voort PG, van der Hoeven J. Acetazolamide mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients. Crit Care. 2006; 10: R14. doi: 10.1186/cc3970.
Garella S, Dana CL, Chazan JA. Severity of metabolic acidosis as a determinant of bicarbonate requirements. N Engl J Med. 1973; 289 (3): 121-126.
Modi N. Clinical implications of postnatal alterations in body water distribution. Semin Neonatol. 2003; 8 (4): 301-306.
Hartnoll G, Betremieux P, Modi N. Body water content of extremely preterm infants at birth. Arch Dis Child Fetal Neonatal. 2000; 83 (1): F56-F59.
Kaplan L, Kellum JA. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med. 2004; 32: 1120-1124.
Balasubramanyan N, Havens PL, Hoffman GM. Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med. 1999; 27: 1577-1581.
Gilfix BM, Bique M, Magder S. A physical chemical approach to
the analysis of acid-base balance in the clinical setting. J Crit Care. 1993; 8: 187-197.