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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2015, Number 2

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Rev Biomed 2015; 26 (2)

search for a therapeutic target

Castro-Torres IG, Bermúdez-Camps IB

Language: Spanish
References: 46
Page: 87-97
PDF size: 306.71 Kb.


ABSTRACT

In the physiopathology of cholesterol gallstones different imbalances are involved, among them are alterations in the secretion of biliary lipids, in the crystallization/nucleation of cholesterol, in the overproduction of mucins, which modify motility of gallbladder, and in the intestinal cholesterol transport. In all these processes many molecules are involved, for example ABCG5, ABCG8, ABCB11 and ABCB4 transporters, MUC genes, which are responsible for expressing mucin, cholecystokinin (CCK), cholecystokinin receptor 1 and Niemann-Pick C1L1 protein (NPC1L1). In this review, we discuss the findings of the studies of these molecules, which have a specific role in the formation of cholesterol gallstones. The modulation of the expression of these proteins can be an important guideline to find out a new therapeutic target for prevention and treatment and of this gallbladder disease.


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